Interactions of aflatoxin B1 and blood components of various species in vitro: interconversion of aflatoxin B1 and aflatoxicol in the blood

Toxicology and Applied Pharmacology
S KumagaiK Aibara

Abstract

The fate of aflatoxin B1 (AFB1) in the blood of various species of animals was studied in vitro. Examination of the distribution of radioactivity in blood incubated with [14C]AFB1 at 37 degrees C showed that high levels of radioactivity were associated with blood cells. The radioactivity was readily removed from the blood cells by washing with fresh plasma, indicating loose binding of AFB1 to blood cells. Most of the radioactivity in plasma was bound to protein. These results suggest that a large part of the AFB1 in blood in vivo may be carried not only by the plasma proteins but also by the blood cells. When chloroform extracts of plasma of [14C]AFB1-treated mouse, rat, duckling, and hamster blood were developed by thin-layer chromatography, high levels of radioactivity were found in both the AFB1 region and the aflatoxicol (AFL) region. Incubation of blood with nonradioactive AFB1 and AFL showed marked interconversion of AFB1 and AFL in the blood of rats, hamsters, mice, and Mongolian gerbils, but not in the blood of guinea pigs, rhesus monkeys, squirrel monkeys, or humans. Interconversion occurred in red blood cell suspensions but not in plasma, indicating that the red blood cells are responsible for AFB1-AFL interconversion...Continue Reading

References

Feb 1, 1976·Toxicology and Applied Pharmacology·T C Campbell, J R Hayes
Apr 21, 1978·Science·Z A Wong, D P Hsieh
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J J Wong, D P Hsieh
Aug 1, 1973·Food and Cosmetics Toxicology·J I DaleziosG N Wogan
Dec 1, 1971·Food and Cosmetics Toxicology·D S Patterson, B A Roberts
Jan 1, 1973·Biochemical Pharmacology·O Bassir, E A Bababunmi
Nov 1, 1970·Toxicology and Applied Pharmacology·J F White, A Rothstein
Jan 1, 1980·Toxicology and Applied Pharmacology·I UenoC L Stone
Aug 1, 1980·Toxicology and Applied Pharmacology·Z A Wong, D P Hsieh

❮ Previous
Next ❯

Citations

Jan 1, 1991·The International Journal of Biochemistry·L H Van den Heever, H W Dirr
Jan 1, 1985·Toxicon : Official Journal of the International Society on Toxinology·J N Neucere, E B Lillehoj
Sep 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·S Kumagai
Dec 12, 2003·Food Additives and Contaminants·M CarvajalA Bolaños
Jan 1, 1989·Toxicology and Applied Pharmacology·S Kumagai
Aug 1, 1995·Bioscience Reports·A O AdebayoO O Olorunsogo
Jul 18, 1984·Biochemical and Biophysical Research Communications·J J Ch'ih, T M Devlin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.