Abstract
Systemic lupus erythematosus (SLE) sera, two classes of serum lipoproteins, and IgG antibodies from SLE and normal sera were tested for their reactivity with a Z-DNA polymer, Br-poly (dG-dC). In all cases preferential binding to Z-DNA over B-DNA was observed. This interaction, for the most part, could be inhibited by the negatively charged phospholipid, cardiolipin, which suggests that most of the anti-Z-DNA activity associated with sera arises from relatively non-specific ionic interactions between proteins and polyanionic molecules. An assay has been described that can eliminate proteins cross-reactive with negatively charged phospholipids.
References
May 1, 1992·Lupus·Y IchikawaS Arimori
Jun 30, 1990·Lancet·M GalliE M Bevers
Jun 15, 1990·Science·A A SinhaH O McDevitt
May 1, 1991·The Biochemical Journal·P KrishnaJ H van de Sande
Jul 1, 1990·Immunology Today·K BrinkmanR J Smeenk
Nov 1, 1990·Journal of Bacteriology·P Krishna, J H van de Sande
Mar 1, 1990·Arthritis and Rheumatism·T J ThomasR P Messner
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H P McNeilS A Krilis
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P KrishnaJ D McGhee
Jun 1, 1985·Molecular Immunology·H KrippnerK Pirlet
Jan 1, 1989·Advances in Immunology·E M Tan
Jun 1, 1985·Immunological Investigations·V KumarE H Beutner
Mar 31, 1988·Biochimica Et Biophysica Acta·P D van Helden, A J Bester
Mar 1, 1988·Arthritis and Rheumatism·T J ThomasR P Messner
Jan 1, 1986·CRC Critical Reviews in Biochemistry·B D Stollar
Apr 1, 1987·European Journal of Immunology·M ZoualiD B Stollar
Jan 1, 1986·Methods in Enzymology·W R Fisher, V N Schumaker
Mar 1, 1973·Arthritis and Rheumatism·B Ginsberg, H Keiser
Jan 11, 1980·Nucleic Acids Research·B BowenH Weintraub
Mar 26, 1984·FEBS Letters·J S LeeL J Latimer
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E M LaferA Rich
Apr 1, 1981·The Journal of Experimental Medicine·E M LaferB D Stollar
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Citations
Oct 17, 2013·Autoimmunity·Zachary Oaks, Andras Perl
Jun 22, 2016·Clinical Reviews in Allergy & Immunology·Wesley H Brooks
Aug 6, 1998·European Journal of Immunology·J CabiedesD Alarcón-Segovia