PMID: 8467564Apr 1, 1993Paper

Interactions of anti-DNA antibodies with Z-DNA

Clinical and Experimental Immunology
P KrishnaJ H van de Sande

Abstract

Systemic lupus erythematosus (SLE) sera, two classes of serum lipoproteins, and IgG antibodies from SLE and normal sera were tested for their reactivity with a Z-DNA polymer, Br-poly (dG-dC). In all cases preferential binding to Z-DNA over B-DNA was observed. This interaction, for the most part, could be inhibited by the negatively charged phospholipid, cardiolipin, which suggests that most of the anti-Z-DNA activity associated with sera arises from relatively non-specific ionic interactions between proteins and polyanionic molecules. An assay has been described that can eliminate proteins cross-reactive with negatively charged phospholipids.

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Citations

Oct 17, 2013·Autoimmunity·Zachary Oaks, Andras Perl
Jun 22, 2016·Clinical Reviews in Allergy & Immunology·Wesley H Brooks

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