PMID: 11606034Oct 19, 2001Paper

Interactions of aspirin and salicylic acid with prednisolone for inhibition of lymphocyte proliferation

International Immunopharmacology
R Ramakrishnan, W J Jusko

Abstract

The anti-inflammatory properties of salicylates and prednisolone were investigated using inhibition of in vitro phytohemagglutinin-stimulated lymphocyte proliferation in human whole blood from healthy male and female subjects. Steroids and salicylates are used in conjunction for the treatment of inflammatory disorders such as rheumatoid arthritis and inhibit the proinflammatory transcription factor, NFKB, by different mechanisms. Data generated using various combinations of these drugs were analyzed using isobolograms and the universal surface response approach based on the Loewe additivity principle. The interaction between aspirin and prednisolone was mildly antagonistic while that between salicylic acid and prednisolone was modestly synergistic at therapeutic concentrations. Further, aspirin was slightly more potent in males, but the nature of the steroid-salicylate interaction was similar across genders. This study helps rationalize part of the beneficial effects of steroids and salicylates in treatment of inflammatory disorders.

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Citations

Nov 16, 2012·Pharmaceutical Research·Dipti K PawaskarWilliam J Jusko
Nov 13, 2012·Critical Reviews in Biomedical Engineering·Hoi-Kei LonWilliam J Jusko
Jun 24, 2003·Journal of Pharmaceutical Sciences·Donald E MagerWilliam J Jusko
Feb 28, 2015·Journal of Epidemiology·Ching-Piao TsaiCharles Tzu-Chi Lee
Dec 25, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·N N GuimarãesK S Cunha
Jan 7, 2005·Clinical Pharmacokinetics·David CzockUlla Häussler
Dec 19, 2018·Cold Spring Harbor Perspectives in Medicine·Corné J Kros, Peter S Steyger

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