Interactions of beta-lactam antibiotics and antineoplastic agents.

Antimicrobial Agents and Chemotherapy
Y UedaI Saikawa

Abstract

The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically isolated strains of four species of gram-negative bacilli. Generally, by the checkerboard dilution method, beta-lactam antibiotics, when tested in combination with mitomycin C, bleomycin, or 5-fluorouracil, showed synergistic action, whereas when tested in combination with carboquone, they showed antagonistic action. Almost no combinations of adriamycin showed the interactions. Among beta-lactam antibiotics, piperacillin was more frequently synergistic than cefoperazone, cefazolin, or carbenicillin when tested in combination with each antineoplastic agent against various species.

References

Mar 15, 1976·Journal of Molecular Biology·L J Gudas, A B Pardee
Nov 1, 1978·Antimicrobial Agents and Chemotherapy·M R MoodyP H Wiernik
Feb 1, 1978·The Journal of Infectious Diseases·M C Berenbaum
Jul 26, 1965·Biochemical and Biophysical Research Communications·N W Coles, R Gross
Mar 1, 1980·Antimicrobial Agents and Chemotherapy·D N Wright, J M Matsen

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Citations

May 1, 1984·Antimicrobial Agents and Chemotherapy·H R BartusS T Crooke
Oct 13, 2007·European Journal of Radiology·Nicolau BeckmannAlexandre Trifilieff
Jun 15, 2016·Journal of Medical Microbiology·Eline VanlanckerTom Van de Wiele
Sep 27, 2007·Journal of Magnetic Resonance Imaging : JMRI·Harry Karmouty-QuintanaNicolau Beckmann
Apr 15, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christine EggerNicolau Beckmann
Jun 3, 2017·The Journal of Antimicrobial Chemotherapy·A E J YsselH P Steenackers

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