Interactions of blockade of nitric oxide synthase and angiotensin-converting enzyme on renal function in conscious rabbits

Journal of Cardiovascular Pharmacology
R G EvansW P Anderson

Abstract

We tested the effects and interactions of blockade of nitric oxide (NO) synthase and angiotensin-converting enzyme (ACE) on renal function. Six rabbits were studied four times, each at 14-day intervals. The treatments were intravenous (i.v.) vehicle, NG-nitro-L-arginine (L-NNA) 5 mg/kg, captopril 500 micrograms plus 3.3 micrograms/kg/min, or L-NNA plus captopril. The studies were performed in random order. Arterial blood pressure (BP), heart rate (HR), and clearance of H2O, Na+, Li+, [3H]inulin [glomerular filtration rate (GRF)], and paraaminohippuric acid (PAH, renal plasma flow) were measured for the hour before treatment and for 3 h after treatment. Renal blood flow (RBF), renal vascular conductance, and GFR were reduced by 36 +/- 4, 41 +/- 4, and 17 +/- 5%, respectively, after L-NNA treatment. Although captopril did not affect these variables significantly when given alone, it completely abolished the effects of L-NNA. After L-NNA administration, sodium excretion decreased by 41 +/- 11%, chiefly attributable to reduced GFR, although increased reabsorption of sodium also contributed. The site of this increased reabsorption was probably the proximal nephron, since Li+ reabsorption (a marker of proximal tubular sodium reabsorp...Continue Reading

Citations

Apr 18, 1997·European Journal of Pharmacology·Y AdachiS Satoh
Oct 27, 1997·Journal of Pharmacological and Toxicological Methods·R G EvansW P Anderson
Dec 18, 2003·Clinical and Experimental Pharmacology & Physiology·Jeremy J OliverRoger G Evans
Feb 1, 1995·Clinical and Experimental Pharmacology & Physiology·R G EvansW P Anderson
Jun 1, 1997·Clinical and Experimental Pharmacology & Physiology·K M StevensonW P Anderson
May 30, 2003·Pharmacological Reviews·Noboru Toda, Tomio Okamura
Mar 3, 2007·Pharmacological Reviews·Noboru TodaTomio Okamura
Mar 13, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Paolo CalzavaccaClive N May

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