Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Mia C AkerfeldtElizabeth J New

Abstract

There is much interest in understanding the mechanisms by which platinum-based anticancer agents enter cells, and the copper transporter CTR1 has been the focus of many recent studies. While there is a clinical correlation between CTR1 levels and platinum efficacy, cellular studies have provided conflicting evidence relating to the relationship between cisplatin and CTR1. We report here our studies of the relationship between cisplatin and copper homeostasis in human colon cancer cells. While the accumulation of copper and platinum do not appear to compete with each other, we did observe that cisplatin perturbs CTR1 distribution within 10 min, a far shorter incubation time than commonly employed in cellular studies of cisplatin. Furthermore, on these short time-scales, cisplatin caused an increase in the cytoplasmic labile copper pool. While the predominant focus of studies to date has been on CTR1, these studies highlight the importance of investigating the interaction of cisplatin with other copper proteins.

References

Aug 1, 1970·Toxicon : Official Journal of the International Society on Toxinology·F E Russell
Sep 3, 1998·The Journal of Biological Chemistry·R L CasarenoJ D Gitlin
Mar 22, 2001·Molecular Pharmacology·V M GonzalezJ M Perez
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiko IshidaIra Herskowitz
Dec 27, 2002·The Journal of Biological Chemistry·Michael J PetrisDennis J Thiele
Sep 1, 2004·Experimental Biology and Medicine·Elizabeth C West, Joseph R Prohaska
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alison K HolzerStephen B Howell
Nov 14, 2006·Biochemical Pharmacology·Jochen ZisowskyUlrich Jaehde
Jul 13, 2007·Nature Reviews. Cancer·Lloyd Kelland
Jul 14, 2007·The Journal of Biological Chemistry·Devis SinaniJaekwon Lee
Jul 5, 2008·The British Journal of Nutrition·Linda J Harvey, Harry J McArdle
Nov 11, 2008·Molecular Pharmacology·Christopher A LarsonStephen B Howell
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Navjotsingh PablaZheng Dong
May 11, 2010·Biochemical Pharmacology·Christopher A LarsonStephen B Howell
Jul 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Swati S MoreKathleen M Giacomini
Jul 27, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Helen H W ChenWu-Chou Su
Oct 11, 2011·Journal of the American Chemical Society·Fabio ArnesanoGiovanni Natile
Sep 27, 2012·Journal of Inorganic Biochemistry·Ganna V KalaydaUlrich Jaehde
Jan 11, 2013·The Journal of Nutrition·Jesse BertinatoStephen Hayward
Aug 31, 2013·Protein and Peptide Letters·Maria E Palm-EsplingPernilla Wittung-Stafshede
Oct 18, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Zheng Dong LiangMacus Tien Kuo
Jan 30, 2014·Chemical Communications : Chem Comm·Linhong ZhaoYangzhong Liu
Nov 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Sheel C DodaniChristopher J Chang
Nov 27, 2014·Metallomics : Integrated Biometal Science·Clara Shen, Elizabeth J New
Jun 13, 2015·Metallomics : Integrated Biometal Science·Chen LinY James Kang
Jul 15, 2015·Oncotarget·Tetsu YamamotoStephen B Howell
Jul 29, 2015·Accounts of Chemical Research·Allegra T AronChristopher J Chang
Aug 28, 2015·Metallomics : Integrated Biometal Science·Delphine DenoyerMichael A Cater
Oct 28, 2015·Chemical Society Reviews·Dominic J HareGawain McColl
May 10, 2016·Metallomics : Integrated Biometal Science·Kristin M BompianiStephen B Howell
Aug 24, 2016·Metallomics : Integrated Biometal Science·Clara ShenElizabeth J New
Nov 25, 2016·The Journal of Biological Chemistry·Haarin ChunByung-Eun Kim

❮ Previous
Next ❯

Citations

Mar 14, 2019·Metallomics : Integrated Biometal Science·Thibault MinerviniMironel Enescu
Apr 6, 2019·Scientific Reports·Timothée RivelSemen Yesylevskyy
Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu
Jun 20, 2019·Nutrients·Ludmila V PuchkovaRoman S Polishchuk
Jun 8, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Panpan LvWenyuan Gao
Nov 28, 2020·Current Topics in Medicinal Chemistry·Tiziano Marzo, Diego La Mendola
Feb 15, 2020·Molecular Pharmaceutics·Chen-Xi YangHu-Lin Jiang
Jul 10, 2019·Journal of the American Chemical Society·Alessia LasorsaFabio Arnesano
Aug 10, 2017·Journal of Inorganic Biochemistry·Marcus E GraziottoElizabeth J New

❮ Previous
Next ❯

Methods Mentioned

BETA
atomic absorption spectroscopy
scraping
Protein Assay
xenograft
Fluorescence
confocal microscopy

Software Mentioned

ImageLab
Fiji
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Eric S KimZahid H Siddik
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Chelsea D LandonMark W Dewhirst
Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Zheng Dong LiangMacus Tien Kuo
© 2022 Meta ULC. All rights reserved