Interactions of complementary PEGylated liposomes and characterization of the resulting aggregates

Langmuir : the ACS Journal of Surfaces and Colloids
Alexandros PantosGeorge Nounesis

Abstract

The interaction of complementary liposomes bearing both recognizable and protective ligands at their external surface has been investigated. Aggregation of hydrogenated phosphatidyl choline/cholesterol (2:1 molar ratio) based liposomes was mediated by the molecular recognition of the complementary phosphate and guanidinium groups incorporated in separate unilamellar liposomes. The phosphate group was incorporated in the bilayer employing dihexadecyl phosphate, while the guanidinium moiety was introduced in the membrane through the incorporation of various guanidinium lipids. For the latter, anchoring ability and primarily introduction of a spacer group between their lipophilic part and the guanidinium group was found to affect the ability for molecular recognition. Also, poly(ethylene glycol) (PEG) introduced in both types of liposomes at various concentrations and up to 15% with respect to cholesterol modifies the interaction effectiveness and morphology of the obtained aggregates. Interaction of these complementary liposomes leads to large precipitating aggregates or fused liposomes, as shown by phase contrast microscopy and dynamic light scattering. Specifically, fusion of liposomes takes place under a nonleaking process inv...Continue Reading

References

Oct 19, 1979·Biochimica Et Biophysica Acta·F OlsonD Papahadjopoulos
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Jan 30, 1991·Biochimica Et Biophysica Acta·R C MacDonaldL R Hu
Nov 27, 1987·Biochimica Et Biophysica Acta·J H IpsenM J Zuckermann
Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Apr 13, 1995·Biochimica Et Biophysica Acta·N Higashi, J Sunamoto
Sep 6, 1994·Chemistry and Physics of Lipids·O G Mouritsen, K Jørgensen
Dec 1, 1995·Trends in Biotechnology·G Gregoriadis
May 1, 1997·Nature·S A WalkerJ A Zasadzinski
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·P CrosassoL Cattel
Aug 1, 2000·Colloids and Surfaces. B, Biointerfaces·D Needham, D H Kim
Apr 3, 2001·International Journal of Pharmaceutics·T KaasgaardK Jørgensen
Feb 6, 2002·Chembiochem : a European Journal of Chemical Biology·C M PaleosD Tsiourvas
Jul 2, 2003·Biophysical Chemistry·Nill BergstrandKatarina Edwards
Nov 18, 2005·Journal of Colloid and Interface Science·Alexandros PantosConstantinos M Paleos
Oct 1, 1992·Biophysical Journal·J L Thewalt, M Bloom
Jun 18, 2001·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·V Marchi-ArtznerJ M Lehn

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Citations

Oct 13, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Constantinos M PaleosZili Sideratou
Jul 20, 2007·Organic & Biomolecular Chemistry·Xi WangSimon J Webb
Feb 25, 2009·Expert Opinion on Drug Delivery·Constantinos M PaleosDimitris Tsiourvas
Nov 18, 2010·Expert Opinion on Drug Delivery·Constantinos M PaleosLeto-Aikaterini Tziveleka
Nov 29, 2005·Journal of Molecular Recognition : JMR·Constantinos M Paleos, Dimitris Tsiourvas
Feb 4, 2006·Macromolecular Bioscience·Leto-Aikaterini TzivelekaConstantinos M Paleos
May 20, 2008·Macromolecular Bioscience·Christina KontoyianniConstantinos M Paleos
Feb 22, 2011·Chembiochem : a European Journal of Chemical Biology·Constantinos M PaleosZili Sideratou
Oct 16, 2009·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Zili SideratouConstantinos M Paleos
May 28, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Constantinos M PaleosAlexandros Pantos
Aug 19, 2014·Colloids and Surfaces. B, Biointerfaces·Zhuang LiYong Huang
Jan 8, 2008·Biochimica Et Biophysica Acta·Alexandros PantosConstantinos M Paleos
Apr 1, 2005·Journal of Microencapsulation
Jul 6, 2014·Organic & Biomolecular Chemistry·Marina ŠekutorRuža Frkanec
Dec 30, 2009·Biomacromolecules·Srinivas ParimiClive A Prestidge
Sep 12, 2008·Journal of Medicinal Chemistry·Theodossis A TheodossiouConstantinos M Paleos
Jan 16, 2007·Molecular Pharmaceutics·Constantinos M PaleosZili Sideratou
Jul 13, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Alexandros PantosGeorge Nounesis
Jul 27, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Alexandros PantosConstantinos M Paleos

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