Interactions of Cu2+ ions with chicken prion tandem repeats

Dalton Transactions : an International Journal of Inorganic Chemistry
Paweł StańczakHenryk Kozłowski

Abstract

The potentiometric and spectroscopic (EPR, UV-Vis, CD) data have shown that the chicken prion hexa-repeat (Ac-His-Asn-Pro-Gly-Tyr-Pro-NH(2)) is a very specific ligand for Cu(2+) ions. The His imidazole is an anchoring binding site, then the adjacent amide nitrogen coordinates as a second donor. The presence of Pro at position 3 induces binding of phenolate oxygen as a third donor atom. The tridentate coordination dominates around physiological pH. Similar to human octapeptide fragments, chicken tandem repeats exhibit a cooperative effect in binding Cu(2+) ions, although chicken peptides are much less effective in metal ion coordination.

References

Mar 1, 1990·International Journal of Peptide and Protein Research·G B Fields, R L Noble
Apr 1, 1985·Cell·B OeschL E Hood
Feb 15, 1995·Biochemical and Biophysical Research Communications·M P HornshawJ M Candy
Dec 31, 1997·Nature·P Brown
Feb 18, 2004·Accounts of Chemical Research·Glenn L Millhauser
Jul 15, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·David R Brown, Henryk Kozlowski
Jul 15, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniela ValensinHenryk Kozlowski

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Citations

Jun 29, 2005·Chemical Communications : Chem Comm·Paweł StańczakHenryk Kozłowski
Apr 12, 2016·Communicative & Integrative Biology·Tomonori KawanoKen Yokawa
Jul 3, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Antonio MagrìEnrico Rizzarelli
Sep 20, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Snezana RajkovićImre Sóvágó
Dec 4, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Ida Noémi JakabBéla Gyurcsik
May 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·András KolozsiBéla Gyurcsik
Jun 1, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Diego La MendolaValeria Zito
Aug 10, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Imre Sóvágó, Katalin Osz
Jun 14, 2020·International Journal of Molecular Sciences·Dong-Ju KimByung-Hoon Jeong
Jul 4, 2018·Prion·Yong-Chan KimByung-Hoon Jeong
Mar 26, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Raffaele P BonomoLaura I Vagliasindi
Aug 25, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Aleksandra KotyniaJustyna Brasuń
Jun 11, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Francesca CamponeschiGianni Valensin
Feb 2, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Laura I VagliasindiGiovanni Tabbì
Mar 27, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Ana FragosoOlga Iranzo
Sep 30, 2009·Journal of Inorganic Biochemistry·Attila JancsóTamás Gajda

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