Interactions of Genes and Sodium Intake on the Development of Hypertension: A Cohort-Based Case-Control Study.

International Journal of Environmental Research and Public Health
Mei-Ling ChenBing-Fang Hwang

Abstract

There have been few studies investigating interactions of G-protein beta3 subunit (GNB3) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity. The study aims to evaluate joint effects of GNB3 polymorphisms and sodium consumption on the development of hypertension. A cohort-based case-control study was conducted in 2014. There are 233 participants with newly diagnosed hypertension in the case group and 699 participants in the gender-matched control group. The primary outcome is the development of hypertension over a 10-year period. The determinants of hypertension were three genotypes of SNP in GNB3 (TT; CT; and CC) and two dietary salt categories on the basis of the level of sodium consumption representing high (>4800 mg/day) and low-sodium (.

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Citations

Mar 13, 2019·Environmental Health and Preventive Medicine·Yoshihiro KokuboAtsushi Goto
Dec 29, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jiajia SongZhangye Xu

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Methods Mentioned

BETA
genotyping
PCR

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