Interactions of gold and silica nanoparticles with plasma membranes get distinguished by the van der Waals forces: Implications for drug delivery, imaging, and theranostics

Colloids and Surfaces. B, Biointerfaces
Haoyuan JingSiddhartha Das

Abstract

Making a nanoparticle (NP) approach and interact with a plasma membrane (PM) through the receptor-ligand interaction is key for applications like targeted drug delivery, cellular imaging, and theranostics. In this paper, we show that the van der Waals (vdW) interactions dominate the electrostatics ensuring that a gold NP approached the PM more spontaneously as compared to a silica NP. The negative σ (charge density) of a PM induces a negative electrostatic potential at the surface of the approaching gold NP and the silica NP; however, there is very little difference between these induced values due to a small electric double layer at the physiological salt concentration (c∞). Hence there is very little difference in the electrostatic repulsion between the two cases, while the PM-NP vdW attraction is much more for the gold NP as a result of a larger Hamaker constant. Therefore, in comparison to the gold NP, the silica NP would (a) undergo a promotion of the specific adhesion and a prevention of the non-specific adhesion simultaneously for a larger σ - c∞ phase space including the physiological conditions, (b) necessitate a larger length of the ligands to trigger spontaneous receptor-ligand interactions, and (c) require a larger ...Continue Reading

Citations

Aug 23, 2019·Journal of Biological Physics·Vladimir P Zhdanov
Nov 27, 2019·Nanotechnology·Francisca Villanueva-FloresLaura A Palomares
Nov 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Loredana Florina LeopoldCristina Coman
Feb 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Harnoor Singh SacharSiddhartha Das

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