Interactions of griseofulvin with cyclodextrins in solid binary systems

Journal of Pharmaceutical Sciences
M D VeigaF Ahsan

Abstract

Griseofulvin/cyclodextrin interactions were investigated in aqueous environment and in solid state. Two cyclodextrin derivatives (beta-cyclodextrin and 2-hydroxypropyl beta-cyclodextrin) were used to prepare different physical mixtures and kneaded systems, and the drug/cyclodextrin ratios were 1:1 and 1:2 mol/mol. Scanning electron microscopy (SEM), hot-stage microscopy (HSM), differential scanning calorimetry (DSC), thermogravimetry (TG), and X-ray powder diffractometry were employed to characterize pure substances and their kneaded counterparts and all of the binary systems. The solubility of griseofulvin was increased in accord with the quantity of cyclodextrin added. HSM examination revealed that 2-hydroxypropyl-beta-cyclodextrin was dissolved in the droplets of melted griseofulvin, but did not show any interactions between melted griseofulvin and beta-cyclodextrin particles. The presence of griseofulvin endothermic peak in the DSC curves of all binary systems suggests the absence of any griseofulvin/cylcodextrin inclusion compound in the solid state. In TG, data of weight loss owing to the dehydration of cyclodextrins was similar for both kneaded systems and physical mixtures. X-ray diffraction patterns exhibited the amorp...Continue Reading

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Citations

Sep 30, 1999·International Journal of Pharmaceutics·J Y JungK H Lee
Feb 17, 2000·International Journal of Pharmaceutics·L W ChanJ C Thenmozhiyal
Jun 1, 2002·Journal of Pharmaceutical and Biomedical Analysis·M D Veiga, M Merino
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Jan 23, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Catarina M FernandesFrancisco J B Veiga
Nov 1, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Laura S S RibeiroFrancisco J B Veiga
Dec 14, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M D Veiga, F Ahsan
Dec 16, 2005·AAPS PharmSciTech·Rajeswari ChallaR K Khar
Oct 6, 2007·AAPS PharmSciTech·Marcílio S S Cunha-FilhoMariana Landín
Oct 6, 2007·AAPS PharmSciTech·Mukesh C Gohel, Krishnakant G Sarvaiya
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Sep 17, 2002·Pharmaceutical Development and Technology·Jaehyeon ParkAeri Kim

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