PMID: 3322264Oct 15, 1987Paper

Interactions of insulin and dexamethasone in the control of pyruvate kinase activity and glucose metabolism in sheep adipose tissue

The Biochemical Journal
C P PlestedR G Vernon

Abstract

1. The Vmax. activity of pyruvate kinase of sheep adipose tissue increased during tissue culture up to 48 h; the increase was blocked by actinomycin D (an inhibitor of transcription) and was promoted by insulin and antagonized by dexamethasone. 2. In contrast with their effects on pyruvate kinase, insulin and dexamethasone acted synergistically to increase the activity of glucose-6-phosphate dehydrogenase of sheep adipose tissue maintained in culture. 3. Insulin stimulated, whereas dexamethasone inhibited, glucose utilization by sheep adipose tissue maintained in culture; the two agents were mutually antagonistic, and their effects were prevented by actinomycin D. 4. Antimycin A (an inhibitor of the electron-transport chain) stimulated glucose uptake and lactate output by sheep adipose tissue in the presence of dexamethasone and insulin, suggesting that the effects of dexamethasone on glucose utilization by sheep adipose tissue were not due to an inhibition of glucose transport. 5. Comparison of these findings with previous studies on the endocrine control of hepatic pyruvate kinase shows that there are major differences in the control of these Vmax. activities in liver and adipose tissue. 6. Although glucocorticoid hormones in...Continue Reading

Citations

Aug 16, 2011·European Journal of Pharmacology·Masao SatoShinya Suzuki
Aug 19, 2007·Journal of Psychiatric Research·M Flechtner-MorsH H Ditschuneit
Apr 1, 1995·Journal of Internal Medicine·H Abrahamsson
Feb 1, 1996·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Y FaulconnierY Chilliard
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·P M Toleikis, D V Godin
May 1, 1995·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·S WastieR G Vernon
May 1, 1992·Metabolism: Clinical and Experimental·D N Brindley

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