PMID: 9437240Jan 23, 1998Paper

Interactions of insulin-like growth factor (IGF)-II and growth hormone in vivo: circulating levels of IGF-I and IGF-binding proteins in transgenic mice

European Journal of Endocrinology
A BlackburnE Wolf

Abstract

To study interactions between insulin-like growth factor-II (IGF-II) and growth hormone (GH) in vivo, we crossed hemizygous transgenic mice carrying phosphoenolpyruvate carboxykinase (PEPCK)-IGF-II fusion genes with hemizygous PEPCK-bovine GH (bGH) transgenic mice. Offspring harbouring both transgenes (IB), the IGF-II transgene (I) or the bGH transgene (B), and non-transgenic littermates (C) were obtained. Blood samples were taken before (end of week 12) and after (end of week 14) the mice had received a diet high in protein and low in carbohydrates to stimulate PEPCK promoter-controlled transgene expression. Mean serum GH concentrations of both B and IB mice corresponded to 900 ng/ml and increased more than twofold (P < 0.001) after 1 week of the high-protein diet. GH concentrations in controls and I mice were less than 20 ng/ml. Serum IGF-II concentrations in I and IB mice were three-to fourfold higher than those in C and B mice. Whereas IGF-II concentrations were not changed by the high-protein diet in the last two groups, serum IGF-II increased significantly in I (P < 0.001) and IB mice (P < 0.05). This increase was significantly (P < 0.05) less pronounced in IB than in C and I mice. Circulating IGF-I concentrations were ab...Continue Reading

Citations

Dec 24, 1998·Molecular and Cellular Endocrinology·V M DirschA M Vollmar
Dec 14, 1999·The Journal of Investigative Dermatology·R WankeE Wolf
Aug 29, 2012·Journal of Oncology·Roberta MalaguarneraAntonino Belfiore
Jan 20, 2011·Clinical Science·Elena ContiMassimo Volpe
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M R SchneiderE Wolf
Sep 13, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E WolfH Lahm

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