Jan 1, 1979

Interactions of low density lipoproteins with glycosaminoglycans and foam cells within the atherosclerotic aorta (author's transl)

Deutsche Zeitschrift für Verdauungs- und Stoffwechselkrankheiten
A W PopowA G Winogradow


Very low and low density lipoproteins (VLDL and LDL) isolated from aorta's intima in salt solution were predominantly, associated in complex with glycosaminoglycans (GAG): hyaluronic acid, chondroitinsulfate A(C), heparin. Heparin was detected mainly in complex, isolated from fibrosis plaque. Studying of interaction between LDL and foam cells showed that cells in situ as far as under their incubation in medium with llow LDL concentration primarily accumulated lipid of lipoprotein particles. Incubation foam cells under increased concentration of lipoprotein in medium led to greater entry of radioactivity into the cells. However, there was less tendency for primarily lipid accumulation. Increase of LDL concentration correlated with larger cell's CO2 production. GAG prevented this effect of LDL. Besides LDL uptake was decreased in this condition too. It is possible that GAG effect lipoprotein properties and in such a way the character of their interaction with cells.

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Tunica Intima
Hyaluronic Acid Test
Free Radicals
Dental Plaque
VLDL Cholesterol Measurement

About this Paper

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.