Interactions of meso-tetra-(4-N-oxyethylpyridyl) porphyrin, its 3-N analog and their metallocomplexes with duplex DNA

Journal of Biomolecular Structure & Dynamics
Y DalyanA S Benight

Abstract

Interactions of meso-tetra-(4-N-oxyethylpyridyl) porphyrin (TOEPyP(4)), its 3-N analog (TOEPyP(3)) and their Co, Cu, Ni, Zn metallocomplexes with duplex DNA have been investigated by uv/visible absorbance and circular dichrosim spectroscopies. Results reveal the interactions of these complexes with duplex DNA are of two types. (1) External binding of duplex DNA by metalloporphyrins containing Zn and Co, and (2) Binding of duplex DNA both externally and internally (by intercalation) by porphyrins not containing metals, and metalloporphyrins containing Cu and Ni. Results indicate that (4N-oxyethylpyridyl) porphyrins intercalate more preferably in the structure of duplex DNA and have weaker external binding than 3N-porphyrins.

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Citations

Jul 27, 2012·Journal of Biomolecular Structure & Dynamics·Cui-Li YuanKe-Zhi Wang
Mar 29, 2011·Biophysical Chemistry·G AnanyanY Dalyan
Jan 17, 2014·Journal of Biomolecular Structure & Dynamics·Jamlet MonaselidzeNune Hakobyan
Dec 11, 2007·International Journal of Toxicology·Gennadi GasparyanRouben Aroutiounian
Aug 3, 2014·Journal of Inorganic Biochemistry·Artak TovmasyanGennadi Gasparyan
Jan 17, 2020·Journal of Biomolecular Structure & Dynamics·Nelli H KarapetyanYeva B Dalyan
Jun 20, 2006·Journal of Biomolecular Structure & Dynamics·A A GhazaryanT V Chalikian
May 19, 2010·Journal of Biomolecular Structure & Dynamics·Y DalyanG Balayan

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