Interactions of mussel-inspired polymeric nanoparticles with gastric mucin: Implications for gastro-retentive drug delivery

Colloids and Surfaces. B, Biointerfaces
Suhair SunoqrotOla Tarawneh

Abstract

Mussel-inspired polydopamine (pD) coatings have several unique characteristics such as durability, versatility, and robustness. In this study, we have designed pD-coated nanoparticles (NPs) of methoxy polyethylene glycol-b-poly(ε-caprolactone) (mPEG-PCL@pD) as prospective nanoscale mucoadhesive platforms for gastro-retentive drug delivery. Successful pD coating on the NPs was confirmed by Transmission Electron Microscopy and X-ray Photoelectron Spectroscopy. Mucoadhesion of pD-coated NPs was investigated in vitro using commercially available mucin under stomach lumen-mimetic conditions. Mucin-NP interactions were monitored by dynamic light scattering, which showed a significant change in particle size distribution of pD-coated NPs at mucin/NP ratios of 1:1, 1:2, and 1:4w/w. Turbidity measurements indicated the formation of large mucin-NP aggregates causing a significant increase in turbidity at mucin/NP ratios of 2:1 and 4:1w/w. pD-coated NPs exhibited a significantly higher mucin adsorption ability compared to uncoated NPs at mucin/NP ratios of 1:4, 1:2, and 1:1w/w. Zeta potential measurements demonstrated that mucin-pD-coated NP interactions were not electrostatic in nature. An ex vivo wash-off test conducted using excised sh...Continue Reading

Citations

Aug 25, 2020·Macromolecular Bioscience·Pan ZhengGao Li
Aug 1, 2020·Biomimetics·Mar Collado-GonzálezFrancisco M Goycoolea
Feb 24, 2021·International Journal of Pharmaceutics·Zhengyang JiaBenjamin Thierry
Jun 25, 2021·Advanced Drug Delivery Reviews·Matthias MarczynskiOliver Lieleg
Sep 20, 2018·ACS Applied Materials & Interfaces·Devang R AminPhillip B Messersmith

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