Interactions of nitrovasodilators, atrial natriuretic peptide and endothelium-derived nitric oxide

Journal of Vascular Research
T MuroharaH Yasue

Abstract

Nitroglycerin (NTG), endothelium-derived relaxing factor (EDRF) and atrial natriuretic peptide (ANP) dilate vessels by a common pathway (cyclic guanosine monophosphate- dependent mechanism). Thus, these vasodilators may potentially influence the vasodilator properties of each other. We examined whether tolerance to NTG influences vasorelaxation to ANP, EDRF and other nitrovasodilators, isosorbide dinitrate (ISDN) and sodium nitroprusside (SNP). Concentration-response curves for various vasodilators during stable contraction to PGF2alpha were examined before and after the induction of NTG tolerance. Rings exposed to NTG (100 microM) for 60 min showed marked impairment of vasorelaxation to NTG itself. This NTG tolerance significantly attenuated vasorelaxation to either ISDN, SNP or EDRF stimulated by bradykinin. In contrast, the NTG tolerance did not alter vasorelaxation to either ANP or isoproterenol. The attenuated responses to NTG, ISDN, SNP and bradykinin recovered in a time-dependent manner during the subsequent washout period, suggesting this inhibition is reversible. The denudation of the endothelium significantly sensitized relaxation to NTG but did not change relaxation to ANP. These results suggest that (1) vasorelaxati...Continue Reading

Citations

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