Interactions of nucleobases with alkali earth metal cations--electrospray ionization mass spectrometric study

European Journal of Mass Spectrometry
Magdalena Frańska

Abstract

Interactions of nucleobases with alkali earth metal cations have been studied by electrospray ionization mass spectrometry (ESI-MS). Nucleobases containing at least one oxygen atom form stable complexes with alkali earth metal cations. This phenomenon can be explained on the grounds of the well known theory of hard and soft acids and bases. Uracil and thymine make complexes only when in their deprotonoted forms. The cations of great radii (Sr(2+), Ba(2+)) are more prone to form complexes of stoichiometry 1:1 with uracil and thymine than the cations of small radii (Mg(2+), Ca(2+)). On the other hand, Mg(2+) forms complexes of stoichiometry 2:1 and 3:2 with uracil and thymine. Gas-phase stabilities of the 1:1 complexes are higher for the cations of small radii, in contrast to the solution stabilities. For cytosine and 9- methylhypoxantine the 1:1 complexes of their deprotonated forms are observed at higher cone voltage as a result of HCl molecule loss from the complexes containing the counter ion (Cl(-)). In solution, more stable complexes are formed with metal cations of low radii. Gas-phase stability of the complexes formed by deprotonated 9- methyl-hypoxantine increases with increasing metal cation radius.

References

May 20, 2000·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·L A Herrero, A Terrón
Jul 27, 2001·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·L Jiang, X A Mao
Apr 12, 2002·Mass Spectrometry Reviews·C A Schalley
Mar 11, 2005·Rapid Communications in Mass Spectrometry : RCM·Magdalena FrańskaMichael Linscheid
Jun 11, 2005·European Journal of Mass Spectrometry·Magdalena Frańska
Dec 22, 2005·Mass Spectrometry Reviews·Valerio B Di Marco, G Giorgio Bombi

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Citations

May 22, 2008·European Journal of Mass Spectrometry·Magdalena Frańska
Aug 16, 2012·Organic & Biomolecular Chemistry·Ane EizaguirreJeanine Tortajada
Jul 22, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jean-Yves SalpinAl Mokhtar Lamsabhi
Nov 4, 2020·Rapid Communications in Mass Spectrometry : RCM·Magdalena FrańskaŁukasz Ławniczak
Oct 1, 2021·Chemical Reviews·Eric LargyValérie Gabelica

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