Interactions of perfluoroalkyl substances with a phospholipid bilayer studied by neutron reflectometry

Journal of Colloid and Interface Science
Shirin NouhiMaja S Hellsing

Abstract

The interactions between perfluoroalkyl substances (PFASs) and a phospholipid bilayer (1,2-dimyristoyl-sn-glycero-3-phosphocholine) were investigated at the molecular level using neutron reflectometry. Representative PFASs with different chain length and functional groups were selected in this study including: perfluorobutane sulfonate (PFBS), perfluorohexanoate (PFHxA), perfluorohexane sulfonate (PFHxS), perfluorononanoate (PFNA), perfluorooctane sulfonate (PFOS), and perfluorooctane sulfonamide (FOSA). All PFASs were found to interact with the bilayer by incorporation, indicating PFAS ability to accumulate once ingested or taken up by organisms. The interactions were observed to increase with chain length and vary with the functional group as SO2NH2(FOSA)>SO2O-(PFOS)>COO-(PFNA). The PFAS hydrophobicity, which is strongly correlated with perfluorocarbon chain length, was found to strongly influence the interactions. Longer chain PFASs showed higher tendency to penetrate into the bilayer compared to the short-chain compounds. The incorporated PFASs could for all substances but one (PFNA) be removed from the lipid membrane by gentle rinsing with water (2mLmin-1). Although short-chain PFASs have been suggested to be the potential...Continue Reading

Citations

Nov 30, 2019·Journal of Endocrinological Investigation·I ŠabovićC Foresta
Aug 9, 2020·International Journal of Environmental Research and Public Health·Dauren MussabekTomomi Imura
Nov 4, 2020·Pflügers Archiv : European journal of physiology·Johannes JägersKatja B Ferenz
Jan 24, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marisa PfohlAngela L Slitt
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Aug 28, 2018·Environmental Science & Technology·Nicole J M FitzgeraldMatt F Simcik
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Mar 12, 2019·Environmental Science & Technology Letters·Clifton DassuncaoElsie M Sunderland
Jun 10, 2020·The Journal of Physical Chemistry. B·Zhiqiang ShenYing Li

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