PMID: 7035941Dec 1, 1981Paper

Interactions of Plasmodium falciparum infected erythrocytes with ligand-coated agarose beads

Molecular and Biochemical Parasitology
P H DavidL D Oligino

Abstract

The binding of normal and Plasmodium falciparum-infected squirrel monkey erythrocytes to columns of ligand-coated agarose beads was compared. Concanavalin A, ricin, soybean and peanut agglutinin-coated beads retain erythrocytes containing large developmental stages of the parasite preferentially to ring-containing erythrocytes or to normal erythrocytes. Binding is inhibited by the sugar corresponding to the lectin's specificity. Preferential binding does not occur with wheat germ or Ulex europaeus agglutinin-coated beads. When infected blood is preincubated in immune serum, infected erythrocytes are specifically retained by Protein A-coated beads. These peculiar binding properties reflect modifications of the infected erythrocyte membrane.

References

Nov 1, 1979·The Journal of Experimental Medicine·S G Langreth, R T Reese
Jan 1, 1979·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Y YuthavongG H Beale
Nov 1, 1977·The Journal of protozoology·G G HolzI W Sherman
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Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·H M Vincent, R J Wilson

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Citations

May 1, 1986·Molecular and Biochemical Parasitology·R Ramasamy, R T Reese
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·P H DavidL D Oligino
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E WinogradI W Sherman
Jan 13, 2011·Memórias do Instituto Oswaldo Cruz·Cristiana S de MacedoLucia Mendonça-Previato
Jan 1, 1985·Immunology Today·M Hommel
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R J Howard

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