PMID: 3759571Aug 1, 1986Paper

Interactions of radiation, cyclophosphamide and nimorazole in a C3H mammary carcinoma in vivo

International Journal of Radiation Oncology, Biology, Physics
C Zachariae, J Overgaard

Abstract

The combined effect of adjuvant Cyclophosphamide (CTX) and the hypoxic radiosensitizer, Nimorazole (NIM), on the radiation response was studied in a C3H mammary carcinoma in CDF1 mice. The effect of NIM and CTX alone or in combination without radiation was assessed by tumor growth delay measured by tumor growth time (TGT). Administration of CTX (100 mg/kg) increased the TGT from 5.2 days in untreated controls to 18.8 days. NIM (1000 mg/kg) had no effect on the TGT. The combined treatment with NIM given 4 hrs before CTX did not increase the TGT compared with CTX alone, which suggests that NIM does not potentiate CTX. The possible effect of an interaction between the therapeutic parameters was determined by administration of NIM, CTX, and radiation in different sequences to C3H mammary tumor bearing mice. The drugs were administered as single doses before or after graded single doses of irradiation. The end point was the radiation dose required to achieve local tumor control in 50% of the mice (TCD50). The enhancement ratio (ER)--defined as TCD50 for radiation alone relative to TCD50 for radiation combined with drug--was 1.2 for CTX given either 15 min before or 4 hrs after radiation. NIM given 30 min before radiation showed an E...Continue Reading

References

Mar 1, 1985·Acta Radiologica. Oncology·H von der Maase, J Overgaard
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·D W Siemann, S A Hill
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·A R TimothyM Overgaard
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·J M Brown
Mar 1, 1982·International Journal of Radiation Oncology, Biology, Physics·N J McNally

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Citations

Aug 21, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Brita Singers SørensenJens Overgaard
Apr 1, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Rumi MurataMichael R Horsman
Dec 23, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·M A Hassan MetwallyJ Overgaard
Mar 12, 2005·International Journal of Health Services : Planning, Administration, Evaluation·Samuel S Epstein
Mar 1, 1989·Cancer Treatment Reviews·D J Stewart, W K Evans

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