PMID: 3253412Dec 1, 1988Paper

Interactions of selenium and cadmium with metallothionein-like and other cytosolic proteins of rat kidney and liver

Journal of Inorganic Biochemistry
A J Viljoen, A L Tappel


Following injection of rats with CdCl2 and [75Se]selenite using five different protocols, the metallothionein-like proteins (MTLPs) of kidney and liver cytosols were fractionated by Sephadex G-75 gel filtration and DEAE Sephacel ion-exchange chromatography. Cd and 75Se distribution in gel-filtration elution profiles was influenced mainly by the time that elapsed between administration of these elements and by the sequence of their administration. There was no Cd redistribution to high molecular weight proteins after long-term Cd injection when rats were killed 48 hr after 75Se injection. Cd was redistributed from MTLP to high molecular-weight proteins in the liver when Cd and 75Se were injected within 1-3 hr of each other. Incorporation of 75Se into MTLP of kidney and liver was independent of Cd injection. The strength of 75Se binding of MTLP was comparable to the covalent binding of 75Se to glutathione peroxidase. Cd and 75Se did not share binding sites on MTLP. In ligand-exchange studies, 1000 ppm Cd did not displace 75Se from MTLP, but 2% 2-mercaptoethanol displaced 10% of the presumably nonspecifically bound 75Se from kidney and liver MTLP. This study provides new information regarding the apparent covalent binding of Se to...Continue Reading


Nov 1, 1978·Chemico-biological Interactions·T A Gasiewicz, J C Smith
Oct 1, 1979·Toxicology and Applied Pharmacology·F N Kotsonis, C D Klaassen
Nov 15, 1977·Biochemical Pharmacology·J K PiotrowskiA Werner
Feb 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·J K Evenson, R A Sunde
May 1, 1966·Biochemistry·P PulidoB L Vallee
Jan 1, 1980·Annals of the New York Academy of Sciences·P D WhangerC L Holcomb
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T Y LiD H Petering
Jul 1, 1980·Journal of Inorganic Biochemistry·G SchmitzC F Shaw
Jan 1, 1980·Toxicology·D SøndergaardG Würtzen

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