Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels.

International Journal of Biological Sciences
Rui-Xing YinMeng Li

Abstract

The interactions of single nucleotide polymorphisms (SNPs) and cigarette smoking on blood pressure levels are limited. The present study was undertaken to detect nine lipid-related SNPs and their interactions with cigarette smoking on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaⅡ, hepatic lipase gene (LIPC) -250G>A, endothelial lipase gene (LIPG) 584C>T, methylenetetrahydrofolate reductase (MTHFR) 677C>T, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T>C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 935 nonsmokers and 845 smokers. The interactions were detected by factorial regression analysis. The frequencies of genotypes (ACAT-1 and LIPG), alleles (ABCA-1), and both genotypes and alleles (LDL-R, LIPC, PPARD and SCARB1) were different between nonsmokers and smokers (P < 0.05-0.001). The levels of pulse pressure (PP, ABCA-1), and systolic, diastolic blood pressure (SBP, DBP) and PP (LIPC) in nonsmokers were different among the genotypes (P < 0.01-0.001). The levels of SBP (ABCA...Continue Reading

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Citations

Oct 31, 2012·International Journal of Molecular Sciences·Rui-Xing YinMeng Li
Apr 15, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sheng-Hua YangJian-Jun Li
Jun 21, 2016·International Journal of Environmental Research and Public Health·Shujun FanGuifan Sun
Oct 18, 2015·The Journal of International Medical Research·Rui-Bin XieWei-Xiong Lin
Feb 6, 2013·Nature Reviews. Cardiology·Adam Csordas, David Bernhard
Jun 27, 2019·Parasitology Research·Thaysa Buss CarvalhoRodrigo Mattos Dos Santos
Dec 12, 2020·Archives of Biochemistry and Biophysics·Yanan GuoXi-Long Zheng

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Methods Mentioned

BETA
genotyping

Software Mentioned

SPSS

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