Interactions of sex and early life social experiences at two developmental stages shape nonapeptide receptor profiles

Integrative Zoology
Lisa C Hiura, Alexander G Ophir

Abstract

Early life social experiences are critical to behavioral and cognitive development, and can have a tremendous influence on developing social phenotypes. Most work has focused on outcomes of experiences at a single stage of development (e.g. perinatal or post-weaning). Few studies have assessed the impact of social experience at multiple developmental stages and across sex. Oxytocin and vasopressin are profoundly important for modulating social behavior and these nonapeptide systems are highly sensitive to developmental social experience, particularly in brain areas important for social behavior. We investigated whether oxytocin receptor (OTR) and vasopressin receptor (V1aR) distributions of prairie voles (Microtus ochrogaster) change as a function of parental composition within the natal nest or social composition after weaning. We raised pups either in the presence or absence of their fathers. At weaning, offspring were housed either individually or with a same-sex sibling. We also examined whether changes in receptor distributions are sexually dimorphic because the impact of the developmental environment on the nonapeptide system could be sex-dependent. We found that differences in nonapeptide receptor expression were region-...Continue Reading

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T R Insel, L E Shapiro
Mar 8, 1985·The Journal of Comparative Neurology·G J DeVriesD F Swaab
Aug 3, 1973·Psychopharmacologia·L Valzelli
Jun 1, 1983·Endocrinologia Japonica·A Matsumoto, Y Arai
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CaldjiM J Meaney
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Sep 6, 2001·Hormones and Behavior·L J YoungT R Insel
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·F ChampagneM J Meaney
May 12, 2005·Hormones and Behavior·James L Goodson
Jun 7, 2005·Hormones and Behavior·Matthew A CooperH Elliott Albers
Mar 18, 2008·Current Opinion in Neurobiology·Catherine Dulac, Tali Kimchi
Jul 29, 2008·Progress in Brain Research·James L Goodson
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Heather E RossLarry J Young
Oct 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kyle L GobroggeZuoxin Wang
Dec 7, 2011·Behavioral Neuroscience·Christopher S GaborElena Choleris
Jan 31, 2012·Hormones and Behavior·Alexander G OphirSteven M Phelps
Jun 2, 2012·Science·Lauren A O'Connell, Hans A Hofmann
Feb 23, 2013·Cell and Tissue Research·Miriam Schneider

❮ Previous
Next ❯

Citations

Sep 27, 2018·Integrative Zoology·Mohamed Kabbaj, Zuoxin Wang
Aug 13, 2020·Frontiers in Ecology and Evolution·Nancy G Solomon, Alexander G Ophir

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.