Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review

Clinical Reviews in Allergy & Immunology
Andrea SukhovEmanual Maverakis

Abstract

Cutaneous psoriasis (e.g., psoriasis vulgaris (PsV)) and psoriatic arthritis (PsA) are complex heterogeneous diseases thought to have similar pathophysiology. The soluble and cellular mediators of these closely related diseases are being elucidated through genetic approaches such as genome-wide association studies (GWAS), as well as animal and molecular models. Novel therapeutics targeting these mediators (IL-12, IL-23, IL-17, IL-17 receptor, TNF) are effective in treating both the skin and joint manifestations of psoriasis, reaffirming the shared pathophysiology of PsV and PsA. However, the molecular and cellular interactions between skin and joint disease have not been well characterized. Clearly, PsV and PsA are highly variable in terms of their clinical manifestations, and this heterogeneity can partially be explained by differences in HLA-associations (HLA-Cw*0602 versus HLA-B*27, for example). In addition, there are numerous other genetic susceptibility loci (LCE3, CARD14, NOS2, NFKBIA, PSMA6, ERAP1, TRAF3IP2, IL12RB2, IL23R, IL12B, TNIP1, TNFAIP3, TYK2) and geoepidemiologic factors that contribute to the wide variability seen in psoriasis. Herein, we review the complex interplay between the genetic, cellular, ethnic, and...Continue Reading

References

Apr 1, 1990·Immunology Today·R Benjamin, P Parham
Aug 1, 1990·Immunology Today·C J Beukelman, A Van Leeuwen
May 1, 1990·Annals of the Rheumatic Diseases·C López-LarreaE Coto
Mar 1, 1987·Annals of the Rheumatic Diseases·N J McHughJ Dagger
Jan 1, 1973·Seminars in Arthritis and Rheumatism·J M Moll, V Wright
Jan 1, 1994·Tissue Antigens·A M LittleP Parham
May 1, 1994·International Journal of Dermatology·D J Trozak
Aug 1, 1993·Arthritis and Rheumatism·M Stefanovic-RacicC H Evans
Jun 1, 1996·Archives of Dermatological Research·I IkäheimoS Silvennoinen-Kassinen
Dec 1, 1996·British Journal of Rheumatology·O Kaipiainen-Seppänen
Nov 14, 1997·Nature Medicine·V IotsovaR Bravo
Jul 23, 1998·Journal of the American Academy of Dermatology·E J Primka, C Camisa
Oct 3, 1999·The Journal of Investigative Dermatology·E MallonC B Bunker
Dec 22, 1999·Immunogenetics·H RammenseeS Stevanović
Feb 15, 2000·The Journal of Biological Chemistry·Y AzumaA Kudo
Feb 19, 2000·Cleveland Clinic Journal of Medicine·C Camisa
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B HomeyA Zlotnik
Feb 24, 2001·Archives of Dermatological Research·C EnerbäckT Martinsson
Feb 14, 2002·The Journal of Investigative Dermatology·Jóhann E GudjónssonHelgi Valdimarsson
Nov 6, 2002·The Journal of Biological Chemistry·Sudeepta AggarwalAustin L Gurney
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bruno GranAbdolmohamad Rostami
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jun 20, 2003·American Journal of Clinical Dermatology·Hugh Zachariae
Dec 10, 2003·The Journal of Experimental Medicine·Craig A MurphyDaniel J Cua
Dec 18, 2003·Clinical and Experimental Immunology·J E GudjonssonH Valdimarsson
Aug 17, 2004·Immunity·Kerstin WolkRobert Sabat
Nov 5, 2004·Genes and Immunity·K WolkR Sabat
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hideaki SugiyamaKevin D Cooper
Jan 1, 2005·Journal of the American Academy of Dermatology·Joel M GelfandDavid J Margolis
Feb 15, 2005·Annals of the Rheumatic Diseases·D D GladmanP Nash
Aug 16, 2005·The Medical Journal of Australia·Peter T Nash, Timothy H J Florin
Dec 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michelle A LowesJames G Krueger

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Citations

Nov 12, 2016·Journal of Autoimmunity·Siba P RaychaudhuriEmanual Maverakis
Aug 30, 2017·Journal of Clinical Medicine·Toru YagoShigeru Kotake
Nov 8, 2018·Journal of Immunology Research·Rambon Shamilov, Brian J Aneskievich
May 31, 2017·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Oct 5, 2019·F1000Research·Vanessa Ocampo D, Dafna Gladman
Dec 21, 2021·Frontiers in Immunology·Miao ChenSheng-Ming Dai

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