Interactions of the microbiome with pharmacological and non-pharmacological approaches for the management of ageing-related musculoskeletal diseases.

Therapeutic Advances in Musculoskeletal Disease
Maria Papageorgiou, Emmanuel Biver

Abstract

Despite major progress in the understanding of the pathophysiology and therapeutic options for common ageing-related musculoskeletal conditions (i.e. osteoporosis and associated fractures, sarcopenia and osteoarthritis), there is still a considerable proportion of patients who respond sub optimally to available treatments or experience adverse effects. Emerging microbiome research suggests that perturbations in microbial composition, functional and metabolic capacity (i.e. dysbiosis) are associated with intestinal and extra-intestinal disorders including musculoskeletal diseases. Besides its contributions to disease pathogenesis, the role of the microbiome is further extended to shaping individuals' responses to disease therapeutics (i.e. pharmacomicrobiomics). In this review, we focus on the reciprocal interactions between the microbiome and therapeutics for osteoporosis, sarcopenia and osteoarthritis. Specifically, we identify the effects of therapeutics on microbiome's configurations, functions and metabolic output, intestinal integrity and immune function, but also the effects of the microbiome on the metabolism of these therapeutics, which in turn, may influence their bioavailability, efficacy and side-effect profile contr...Continue Reading

References

Feb 1, 1995·Bioscience, Biotechnology, and Biochemistry·O ChonanM Watanuki
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E G Van den HeuvelG Schaafsma
Jun 27, 2000·The Journal of Nutrition·C C Metges
Dec 9, 2000·The Journal of Nutrition·E G van den HeuvelT Muijs
Apr 5, 2001·Japanese Journal of Pharmacology·Y HoriK Horie
Sep 26, 2003·American Journal of Preventive Medicine·Edward M CastilloElizabeth Barrett-Connor
Jun 24, 2004·Arzneimittel-Forschung·Laurence BartheGeorges Houin
Mar 8, 2005·Nutrition and Cancer·Shusuke TodenMichael A Conlon
May 5, 2007·The Journal of Physiology·Satoshi FujitaBlake B Rasmussen
May 6, 2008·The American Journal of Medicine·Karina M BergJulia H Arnsten
Jun 12, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A Díez-Pérez, J González-Macías
Oct 22, 2008·The Journal of Nutrition·Tony RajAnura V Kurpad
Aug 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·T Andrew ClaytonJeremy K Nicholson
Jan 26, 2011·Nature Reviews. Endocrinology·Martin Hewison
Mar 11, 2011·The American Journal of Clinical Nutrition·Wendy R RussellHarry J Flint
May 12, 2011·Journal of Dental Research·I Brook
May 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kun ZhuRichard L Prince
Aug 3, 2011·Gastroenterology Research and Practice·Sonia S Yoon, Jun Sun
Apr 11, 2012·Journal of Pharmaceutical Sciences·Alyaa IbrahimFakhreddin Jamali
May 4, 2012·The American Journal of Clinical Nutrition·María Isabel Queipo-OrtuñoFrancisco J Tinahones
Nov 28, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anne-Marie DavilaDaniel Tomé
Dec 25, 2012·Journal of Translational Medicine·Roberto FloresJames J Goedert
Jul 9, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Kyle S SaittaUrs A Boelsterli
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jan 30, 2014·International Journal of Women's Health·Richa SoodLynne T Shuster
Mar 19, 2014·PloS One·Claes OhlssonKlara Sjögren
Mar 29, 2014·Journal of Cellular Physiology·Robert A BrittonLaura R McCabe
Apr 23, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·H BliddalR Christensen
Aug 22, 2014·Journal of Strength and Conditioning Research·Yi Ju HsuHsiao-Li Chuang

❮ Previous
Next ❯

Citations

Sep 8, 2021·Journal of Cellular and Molecular Medicine·Weichun ChenXiao Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Seminars in Reproductive Medicine
Amanda L PrinceKjersti M Aagaard
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Claire J StevesTim D Spector
Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
Diana MartinsFernando Schmitt
© 2021 Meta ULC. All rights reserved