Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia

Neuropharmacology
Nian GongYong-Xiang Wang

Abstract

A series of experiments using technologies of gene mutation and silencing as well as chemical biology have demonstrated that spinal D-amino acid oxidase (DAAO) contributes to the development of central sensitization-mediated chronic pain and might be a potential molecular target for the treatment of chronic pain. DAAO inhibitors are now under clinical investigations for the management of chronic neuropathic pain. This study examined the interactions between morphine and the DAAO inhibitor CBIO (5-chloro-benzo[d]isoxazol-3-ol) in pain and analgesia tolerance mainly in the formalin test. Given subcutaneously CBIO acutely interacted with morphine in analgesia in an additive manner both in the acute nociception settings (the formalin acute phase nociception, hot-plate test and tail immersion test) and in formalin-induced tonic pain. Bi-daily exposure of CBIO given subcutaneously for 7 days did not produce self-tolerance to analgesia or cross-tolerance to morphine whereas 7-day subcutaneous morphine induced self-tolerance to analgesia but not cross-tolerance to CBIO. More importantly, subcutaneous co-administrations or even single dose of CBIO completely prevented or reversed morphine tolerance to analgesia (exhibited by a single do...Continue Reading

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Citations

Aug 16, 2012·Amino Acids·Masahiro YamanakaRyuichi Konno
Sep 22, 2012·Amino Acids·Jin-Lu HuangYong-Xiang Wang
Oct 16, 2013·Peptides·Richard J Bodnar
Feb 29, 2016·Pharmacological Reports : PR·Hong WeiAntti Pertovaara
Apr 9, 2015·Journal of Pharmaceutical and Biomedical Analysis·Shuai MaYong-Xiang Wang
Jul 18, 2015·Neuroscience Letters·Yan LefèvreDaniel L Voisin
Aug 21, 2013·Pharmacology, Biochemistry, and Behavior·Hong WeiAntti Pertovaara
Mar 23, 2013·The Journal of Pharmacology and Experimental Therapeutics·Seth C HopkinsThomas H Large
Oct 21, 2019·Chinese Journal of Integrative Medicine·Usman AliYong-Xiang Wang
Mar 13, 2021·Pharmacology Research & Perspectives·Hao LiuMei-Xian Ou

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