Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection

Virology
Vladimir NovitskyM Essex

Abstract

We investigated the interactive relationship between proviral DNA load and virus-specific IFN-gamma-secreting T cell responses in HIV-1C infection. The presence or absence of correlation, and inverse or direct type of correlation, if any, were dependent on targeted viral gene product. Responses to Gag p24 or to Pol were associated with lower proviral DNA load. Associations between proviral DNA load and T cell responses did not necessarily mirror relationships between plasma RNA load and T cell responses. An interaction analysis showed a synergy in that lower proviral DNA and lower plasma RNA load were associated with high Gag p24-specific IFN-gamma-secreting T cell response (interaction test P = 0.0003). Our findings support the idea that HIV proteins have differential value for vaccine design, and suggest that, for HIV-1C, Gag p24 may be one of the most attractive regions to include in vaccine designs to control both plasma RNA load and cell-associated proviral DNA load.

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Citations

Mar 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vladimir NovitskyM Essex
Feb 10, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Daniel Scott-AlgaraFlorence Buseyne
Jan 1, 2010·Viruses·Vlad NovitskyMax Essex
Jun 26, 2013·Nature Reviews. Immunology·Bruce D Walker, Xu G Yu
Nov 24, 2018·Scientific Reports·Sofie RutsaertLinos Vandekerckhove
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carina L PérezAnnika C Karlsson

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