Interactive control of renal function by alpha 2-adrenergic system and nitric oxide: role of angiotensin II

Journal of Cardiovascular Pharmacology
V VallonS C Thomson

Abstract

We studied the role of angiotensin II (AII) in the interactive control of renal function by the alpha 2-adrenergic system and nitric oxide (NO) in adult male Munich Wistar rats 5-7 days after ipsilateral renal denervation (DNX). Renal micropuncture was used under euvolemic conditions before (period 1) and during (period 2) systemic inhibition of NO synthase (NOS) with NG-monomethyl-L-arginine (L-NMMA) in three groups. Group 1 served as a DNX control. In group 2, the alpha 2-adrenergic agonist B-HT 933 (BHT) was infused systemically throughout the experiment. In group 3, the AII-receptor blocker, Iosartan (LOS), was infused before period 2 as well as throughout infusion of BHT. L-NMMA increased blood pressure (BP) to a similar degree in all three groups. In group 1, infusion of L-NMMA did not affect glomerular hemodynamics or tubular function. With BHT in group 2, L-NMMA reduced absolute proximal tubular reabsorption (APR) and by reducing nephron plasma flow (SNPF) and glomerular ultrafiltration coefficient (LpA) caused nephron filtration rate (SNGFR) to decrease, a response described in innervated kidneys. LOS in group 3 abrogated the BHT-facilitated reduction of LpA and SNGFR but not of SNPF and APR in response to L-NMMA. In g...Continue Reading

Citations

Mar 25, 2006·The Journal of Clinical Investigation·Scott C ThomsonVolker Vallon
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allen W CowleyAi-Ping Zou
Jul 17, 1999·The American Journal of Physiology·I HernándezF J Fenoy
Jun 11, 1999·The American Journal of Physiology·F WuD L Mattson
May 20, 2020·Cardiovascular Therapeutics·William A Pettinger, Edwin K Jackson
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Wei WangRobert W Schrier
Jul 18, 2001·American Journal of Physiology. Renal Physiology·M PorstR Veelken

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