Interactive Effects Between Exercise and Serotonergic Pharmacotherapy on Cortical Reorganization After Spinal Cord Injury

Neurorehabilitation and Neural Repair
Guglielmo FoffaniKaren A Moxon

Abstract

In rat models of spinal cord injury, at least 3 different strategies can be used to promote long-term cortical reorganization: (1) active exercise above the level of the lesion; (2) passive exercise below the level of the lesion; and (3) serotonergic pharmacotherapy. Whether and how these potential therapeutic strategies-and their underlying mechanisms of action-interact remains unknown. Methods In spinally transected adult rats, we compared the effects of active exercise above the level of the lesion (treadmill), passive exercise below the level of the lesion (bike), serotonergic pharmacotherapy (quipazine), and combinations of the above therapies (bike+quipazine, treadmill+quipazine, bike+treadmill+quipazine) on long-term cortical reorganization (9 weeks after the spinal transection). Cortical reorganization was measured as the percentage of cells recorded in the deafferented hindlimb cortex that responded to tactile stimulation of the contralateral forelimb. Results Bike and quipazine are "competing" therapies for cortical reorganization, in the sense that quipazine limits the cortical reorganization induced by bike, whereas treadmill and quipazine are "collaborative" therapies, in the sense that the reorganization induced b...Continue Reading

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Citations

May 27, 2016·Cerebral Cortex·Desire Humanes-ValeraJuan Aguilar
May 18, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mariana Cardoso MeloAlcimar Barbosa Soares
Aug 10, 2019·Neural Regeneration Research·Andrew R Brown, Marina Martinez
May 16, 2020·Exercise and Sport Sciences Reviews·Joseph F WelchGordon S Mitchell
Jan 16, 2021·Cells·Ganchimeg DavaaJung Keun Hyun
Jun 3, 2021·International Journal of Molecular Sciences·Jadwiga N BilchakMarie-Pascale Côté

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