PMID: 8584986Jan 1, 1995Paper

Interactive effects of alcohol and diabetes during pregnancy on the rat fetus

Teratogenesis, Carcinogenesis, and Mutagenesis
Y LinJ Leichter

Abstract

To determine the effect of maternal diabetes and alcohol intake, separately and in combination, on fetal growth and development, pregnant rats were divided into four groups: diabetic (D), diabetic plus alcohol (DA), control (C), and control plus alcohol (CA). Diabetes was induced by administration of streptozotocin before mating and alcohol was administered by gavage (2 g/kg body weight/day) on days 6-11 of gestation. Both diabetic groups (D and DA) had significantly lower weight gain during pregnancy compared to the controls (C and CA), despite the fact that the former consumed more food and water. Alcohol treatment resulted in reduced water and food intake and lower weight gain in the diabetic rats (DA), but not in the non-diabetic rats (CA), compared to their respective controls (D and C). On day 21 of gestation fetal body weights were significantly less and placental weights were significantly greater in the diabetic groups (D and DA) compared with the non-diabetic groups (C and CA). Differences in fetal and placental weights between rats exposed and not exposed to alcohol (C vs. CA and D vs. DA) were not significant. The number of fetuses with external malformations was significantly greater in the litters of alcohol expos...Continue Reading

References

May 11, 1978·The New England Journal of Medicine·S K Clarren, D W Smith
Jun 1, 1977·Teratology·G F Chernoff
Jan 1, 1987·Biology of the Neonate·J D Baird, L Aerts
Feb 1, 1985·Biochemical Society Transactions·U J ErikssonJ Styrud
Jun 1, 1982·Teratology·J L Mills
Jan 1, 1982·Diabetes·D L Coleman

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