PMID: 8941542Nov 1, 1996Paper

Interactive effects of denervation and malnutrition on diaphragm structure and function

Journal of Applied Physiology
M I LewisG C Sieck

Abstract

The purpose of this study was to examine the interactive effects of unilateral denervation (DN) and prolonged malnutrition (MN) on the structure and function of the diaphragm muscle (Dia). Four groups of rats were studied: control (Con), MN, DN, and DN-MN. MN began 2 wk after DN and lasted 4 wk. In both the DN and DN-MN groups, the relative loss in Dia weight exceeded the relative change in body weight. Compared with the Con group, Dia specific force was reduced by approximately 40% in both the DN and DN-MN groups but was unaffected in the MN group. Dia fatigue resistance improved in all experimental groups but to a greater extent in the DN and DN-MN groups. In both the DN and DN-MN groups, approximately 50% of Dia fibers were classified as type IIc, whereas fiber type proportions did not change in the MN group. In the DN group, only type IIb/x fibers atrophied, whereas all fiber types atrophied in the MN and DN-MN groups. We conclude that in the DN-MN group the reduction in specific force combined with the reduction in total cross-sectional area of the muscle significantly curtails Dia force-generating capacity.

References

Apr 15, 1976·The Biochemical Journal·D F Goldspink
Sep 1, 1992·Journal of Applied Physiology·M I Lewis, G C Sieck
Apr 1, 1992·Journal of Applied Physiology·W Z Zhan, G C Sieck
May 1, 1989·Journal of Applied Physiology·G C SieckC E Blanco
Feb 1, 1985·Muscle & Nerve·M MüntenerC W Heizmann
Feb 1, 1986·Journal of Applied Physiology·M I LewisM J Belman
Apr 1, 1985·Journal of Applied Physiology·S G KelsenS Kapoor
Oct 1, 1970·Archives of Neurology·M H Brooke, K K Kaiser
Mar 1, 1969·The American Journal of Physiology·R ZakM Rabinowitz
May 1, 1982·Experimental Neurology·G F Gauthier, A W Hobbs
Jul 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·W L IsleyD R Clemmons
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C W HeizmannA M Rowlerson
Sep 1, 1981·Muscle & Nerve·D C DuBois, R R Almon
Jan 1, 1981·The Journal of Physiology·H J FinolR Owens
Jun 1, 1994·American Journal of Respiratory and Critical Care Medicine·G Le BourdellesM Aubier
Aug 1, 1994·The American Journal of Physiology·L SchulteS Kandarian
Sep 1, 1995·Journal of Applied Physiology·W Z ZhanG C Sieck
Nov 1, 1995·Journal of Applied Physiology·G C SieckJ F Watchko
Nov 1, 1995·Journal of Applied Physiology·H MiyataG C Sieck

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Citations

Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Liying YangBasil J Petrof
Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·Gábor Z RáczMarc Decramer
Jun 27, 2003·American Journal of Respiratory and Critical Care Medicine·Franco Laghi, Martin J Tobin
Jun 9, 2007·Journal of Applied Physiology·Gary C SieckY S Prakash
Dec 9, 2010·The Journal of Toxicological Sciences·Ryu FujikawaToshiaki Ishii
May 31, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·W N WelvaartC A C Ottenheijm
Mar 30, 2019·Experimental Physiology·Matthew J FogartyGary C Sieck
May 3, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sarah M GreisingGary C Sieck
Oct 12, 1999·Journal of Applied Physiology·C CoiraultY Lecarpentier
Jun 15, 2004·Journal of Applied Physiology·Cristina Márcia DiasPatricia R M Rocco
Nov 2, 2002·American Journal of Respiratory and Critical Care Medicine·Franco LaghiMartin J Tobin
Apr 22, 2003·Journal of Applied Physiology·Paige C GeigerGary C Sieck
Jan 24, 2004·American Journal of Respiratory and Critical Care Medicine·Theodoros Vassilakopoulos, Basil J Petrof
Feb 6, 2002·Medicine and Science in Sports and Exercise·Joshua R RodmanGaspar A Farkas
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Catherine S H Sassoon
Feb 6, 2010·Critical Care Medicine·Leigh Ann Callahan, Gerald S Supinski
Aug 31, 2020·Drug Discovery Today. Disease Models·Matthew J Fogarty, Gary C Sieck
May 1, 2021·Journal of Clinical Medicine·Robert T MankowskiScott C Brakenridge

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