PMID: 9194524May 1, 1997Paper

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
S AmbsC C Harris

Abstract

The tumor suppressor gene product p53 plays an important role in the cellular response to DNA damage. DNA damage can lead to p53-mediated growth arrest and apoptosis. High concentrations of nitric oxide (NO) and NO metabolites such as peroxynitrite and NO2 cause DNA damage and have been shown to be mutagenic. Furthermore, NO induces p53 accumulation and, as part of a feedback loop, p53 mediates transcriptional transrepression of inducible nitric oxide synthase. Recent studies have shown increased expression and activity of nitric oxide synthase isoforms in human cancer. NO has both genotoxic and angiogenic properties, so that increased NO production may select mutant p53 cells and contribute to human carcinogenesis and tumor progression.

Citations

Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·S AmbsC C Harris
Jun 11, 1999·International Journal of Cancer. Journal International Du Cancer·A OrucevicP K Lala
Sep 17, 1999·São Paulo Medical Journal = Revista Paulista De Medicina·B M Tavares MurtaE F Murta
Aug 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Q XiongK Xie
Sep 11, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Peter A BrennanJohn D Langdon
May 26, 2004·The American Journal of Clinical Nutrition·Susanna C LarssonAlicja Wolk
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Douglas T HessJonathan S Stamler
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiangdong LeKeping Xie
Oct 21, 2010·The Journal of Biological Chemistry·Yiping Huang, Edward A Ratovitski
Oct 5, 2011·Antioxidants & Redox Signaling·Valeria Gabriela Antico ArciuchMaría Cecilia Carreras
Aug 24, 2013·International Journal of Oral Science·Wioletta Ratajczak-WronaStanislawa Zyta Grabowska
Sep 11, 2017·Environmental Science and Pollution Research International·Rasha Abu-KhudirTarek M Mohamed
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yuk-Kwan ChenLi-Min Lin
Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·R RalhanM Mathur
Jan 31, 2002·World Journal of Gastroenterology : WJG·Zun-Wu Zhang, Michael JG Farthing
Jul 20, 2004·Journal of Cellular Biochemistry·Ziv Radisavljevic
Oct 25, 2003·The Journal of Biological Chemistry·Chi-Hui Tang, Elizabeth A Grimm
Mar 30, 2007·Digestive Diseases and Sciences·Yildiz DincerTülay Akcay
Sep 23, 2006·Medicinal Research Reviews·Simone MocellinDonato Nitti
May 12, 2000·Critical Care Medicine·L LiaudetC Szabó
Jun 17, 2004·Environmental and Molecular Mutagenesis·Julie E GoodmanCurtis C Harris
Nov 24, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Isabela W CunhaFernando A Soares
Jun 27, 2007·European Journal of Nutrition·Carsten N GuttMarkus W Büchler
Jul 5, 2005·Expert Opinion on Investigational Drugs·S P Fricker
Oct 19, 2002·Critical Reviews in Clinical Laboratory Sciences·Gunther GuetensErnst A de Bruijn
Sep 18, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Q ShiK Xie
Jan 17, 2003·Cell Research·Weiming XuIan G Charles
Aug 29, 2006·World Journal of Gastroenterology : WJG·Maria D BegnamiFernando A Soares
Jun 8, 2012·Basic & Clinical Pharmacology & Toxicology·Kyung Im KimJung Mi Oh
Nov 1, 2016·Antioxidants & Redox Signaling·Graciele Almeida de OliveiraDavid A Wink

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