Interactive exploration of neuroanatomical meta-spaces.

Frontiers in Neuroinformatics
Shantanu H JoshiArthur W Toga

Abstract

Large-archives of neuroimaging data present many opportunities for re-analysis and mining that can lead to new findings of use in basic research or in the characterization of clinical syndromes. However, interaction with such archives tends to be driven textually, based on subject or image volume meta-data, not the actual neuroanatomical morphology itself, for which the imaging was performed to measure. What is needed is a content-driven approach for examining not only the image content itself but to explore brains that are anatomically similar, and identifying patterns embedded within entire sets of neuroimaging data. With the aim of visual navigation of large- scale neurodatabases, we introduce the concept of brain meta-spaces. The meta-space encodes pair-wise dissimilarities between all individuals in a population and shows the relationships between brains as a navigable framework for exploration. We employ multidimensional scaling (MDS) to implement meta-space processing for a new coordinate system that distributes all data points (brain surfaces) in a common frame-of-reference, with anatomically similar brain data located near each other. To navigate within this derived meta-space, we have developed a fully interactive 3D ...Continue Reading

Citations

Jan 12, 2013·Journal of Digital Imaging·Chisako MuramatsuHiroshi Fujita
Dec 17, 2010·International Journal of Computer Assisted Radiology and Surgery·Wieslaw L NowinskiKang Sim
Apr 25, 2012·International Journal of Computer Assisted Radiology and Surgery·Thomas KerwinHan-Wei Shen
Nov 10, 2013·Brain Imaging and Behavior·John Darrell Van HornVaughan Greer
Jan 31, 2012·Neuroimaging Clinics of North America·Arthur W Toga

❮ Previous
Next ❯

Methods Mentioned

BETA
feature extraction
MDS

Software Mentioned

Open GL
VDM
Google Earth
LONI
LONI IDA
Photosynth
LONI Pipeline
Brain Extraction Tool
Windows
Analyze

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.