PMID: 7850740Nov 1, 1994

Interactive segmentation of cerebral gray matter, white matter, and CSF: photographic and MR images

Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society
T Q BartlettR Walkup


Digital photography of postmortem brain slices was compared with magnetic resonance imaging (MRI) for morphological analysis of human brain atrophy. In this study, we used two human brains obtained at autopsy: a cognitively defined nondemented control (70-yr-old male) and a demented Alzheimer's disease (AD) subject (82-yr-old female). For each of two brains, interactive manual image segmentation was performed by two observers on two image sets: (a) four coronal T1-weighted MR images (5 mm slices); and (b) four digitized photographic images from comparable rostrocaudal levels. Microcomputer image analysis software was used to measure the areas of three segmented cerebral compartments--gray matter (GM), white matter (WM) and CSF--for both image types. Resegmentation error was defined as the absolute difference between the areas derived from two segmentation trials divided by the value from trial 1 and multiplied by 100. This yielded the percent difference between the area measurements from the two trials. We found intra-observer agreement was better (error rates 1-18%) than inter-observer agreement (3-70%) with best agreement for WM and least for CSF, the smallest object class. MRI overestimated GM area relative to digitized phot...Continue Reading


Mar 1, 1992·Journal of Computer Assisted Tomography·C DeCarliB Horwitz
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R C GurD Berretta
Dec 1, 1990·Biological Psychiatry·M C de LacosteD J Woodward
Apr 1, 1981·Journal of the Neurological Sciences·B M Hubbard, J M Anderson


Oct 20, 2001·Journal of Neuroscience Methods·S S YooP Saiviroonporn
Feb 10, 1999·Investigative Radiology·A MahrW Schlegel
Jan 16, 2013·TheScientificWorldJournal·Ali Reza RezaeeMassoud Houshmand
Jun 6, 1998·Otolaryngologic Clinics of North America·G J WietD J Sessanna
Apr 9, 1998·IEEE Transactions on Medical Imaging·P C TeoB A Wandell
Mar 7, 2019·Journal of Healthcare Engineering·Zhenglun KongShengpu Xu

Related Concepts

Familial Alzheimer Disease (FAD)
Cerebrospinal Fluid
Optical Image Reconstruction
Magnetization Transfer Contrast Imaging
Personal Computers
Signal Processing, Digital

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.