PMID: 7850740Nov 1, 1994

Interactive segmentation of cerebral gray matter, white matter, and CSF: photographic and MR images

Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society
T Q BartlettR Walkup

Abstract

Digital photography of postmortem brain slices was compared with magnetic resonance imaging (MRI) for morphological analysis of human brain atrophy. In this study, we used two human brains obtained at autopsy: a cognitively defined nondemented control (70-yr-old male) and a demented Alzheimer's disease (AD) subject (82-yr-old female). For each of two brains, interactive manual image segmentation was performed by two observers on two image sets: (a) four coronal T1-weighted MR images (5 mm slices); and (b) four digitized photographic images from comparable rostrocaudal levels. Microcomputer image analysis software was used to measure the areas of three segmented cerebral compartments--gray matter (GM), white matter (WM) and CSF--for both image types. Resegmentation error was defined as the absolute difference between the areas derived from two segmentation trials divided by the value from trial 1 and multiplied by 100. This yielded the percent difference between the area measurements from the two trials. We found intra-observer agreement was better (error rates 1-18%) than inter-observer agreement (3-70%) with best agreement for WM and least for CSF, the smallest object class. MRI overestimated GM area relative to digitized phot...Continue Reading

References

Mar 1, 1992·Journal of Computer Assisted Tomography·C DeCarliB Horwitz
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R C GurD Berretta
Dec 1, 1990·Biological Psychiatry·M C de LacosteD J Woodward
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Citations

Oct 20, 2001·Journal of Neuroscience Methods·S S YooP Saiviroonporn
Feb 10, 1999·Investigative Radiology·A MahrW Schlegel
Jan 16, 2013·TheScientificWorldJournal·Ali Reza RezaeeMassoud Houshmand
Jun 6, 1998·Otolaryngologic Clinics of North America·G J WietD J Sessanna
Apr 9, 1998·IEEE Transactions on Medical Imaging·P C TeoB A Wandell
Mar 7, 2019·Journal of Healthcare Engineering·Zhenglun KongShengpu Xu

Related Concepts

Familial Alzheimer Disease (FAD)
Atrophic
Brain
Cerebrospinal Fluid
Optical Image Reconstruction
Magnetization Transfer Contrast Imaging
Personal Computers
Ultramicrotomy
Photography
Signal Processing, Digital

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