Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) analysis of pump thrombosis in the HeartMate II left ventricular assist device

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
James K KirklinMarissa A Miller

Abstract

Pump thrombosis remains an uncommon but potentially catastrophic complication of durable continuous-flow left ventricular assist devices (LVAD). A perceived increase in the incidence of pump thrombosis in the HeartMate II (HMII) LVAD (Thoratec, Pleasanton, CA) by clinicians prompted this analysis of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database. Between 2006 and June 2013, 8,988 United States patients aged older than 18 years received a durable LVAD. Of these, 6,910 adult patients from 132 institutions who received a HMII LVAD were entered in the INTERMACS database and constitute the study group for this analysis. Overall survival (with censoring at transplant or explant for recovery) with the HMII LVAD was 80% at 1 year and 69% at 2 years and was not significantly different when stratified by era of implant. Freedom from device exchange or death due to thrombosis decreased from 99% at 6 months in 2009 to 94% in 2012 (p < 0.0001). Multivariable hazard function analysis showed risk factors for pump thrombosis included later implant year (p < 0.0001), younger age (p < 0.0001), higher creatinine (p = 0.002), larger body mass index (p = 0.004), white race (p = 0.0004), left ventricular ...Continue Reading

References

Oct 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Nov 26, 2008·The Journal of Thoracic and Cardiovascular Surgery·Ranjit JohnAndrew Boyle
Jun 2, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Lynne Warner StevensonJames K Kirklin
Jul 18, 2009·Journal of the American College of Cardiology·Francis D PaganiUNKNOWN HeartMate II Investigators
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Subha V RamanBenjamin Sun
Jul 20, 2010·Interactive Cardiovascular and Thoracic Surgery·Naveen L PereiraSoon J Park
Jan 11, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Jul 17, 2012·The Journal of Thoracic and Cardiovascular Surgery·James K KirklinJames B Young
Dec 25, 2012·The Annals of Thoracic Surgery·Nader MoazamiUNKNOWN HeartMate II Investigators
Jan 22, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Melana YuzefpolskayaUlrich P Jorde
Jan 29, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Jun 26, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Daniel J GoldsteinUlrich Jorde
Aug 24, 2013·The Annals of Thoracic Surgery·Sharven TaghaviAbeel A Mangi
Sep 3, 2013·Journal of the American College of Cardiology·Matthew C BunteMaria M Mountis
Sep 12, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John M StulakFrancis D Pagani

❮ Previous
Next ❯

Citations

Mar 17, 2015·JACC. Heart Failure·Randall C Starling
Apr 11, 2014·The New England Journal of Medicine·J Eduardo RameMichael A Acker
Apr 11, 2014·The New England Journal of Medicine·John M Stulak, Simon Maltais
Apr 11, 2014·The New England Journal of Medicine·Randall C StarlingNicholas G Smedira
Apr 17, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christopher T SalernoMary Norine Walsh
Dec 2, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Omar Wever-Pinzon, Ulrich P Jorde
Aug 12, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ali J MehrChandra Kunavarapu
Aug 3, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Justin FriedNir Uriel
Oct 7, 2014·The Canadian Journal of Cardiology·Michel Carrier, Louis P Perrault
Nov 3, 2015·Expert Review of Cardiovascular Therapy·Erin M SchumerMark S Slaughter
Sep 5, 2014·Current Opinion in Organ Transplantation·James K Kirklin
Mar 19, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Amresh RainaRaymond L Benza
Apr 20, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Keyur B Shah, Michael C Kontos
Feb 29, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kristin M KostickJ S Blumenthal-Barby
Dec 23, 2015·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S AkinK Caliskan
Jan 12, 2016·Annals of Cardiac Anaesthesia·Beth T WebberYiliam F Rodriguez-Blanco
Oct 20, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jenica N UpshawDavid DeNofrio
Aug 27, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Douglas L JenningsMichael A Shullo
Dec 26, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Francis D Pagani
Aug 19, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason N KatzUNKNOWN TRACE study
Aug 25, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Robert M AdamsonWalter P Dembitsky
Oct 29, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Emer JoyceMandeep R Mehra
Nov 2, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Dec 19, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Garrick C StewartMandeep R Mehra
Dec 19, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinLynne W Stevenson
Dec 19, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John M StulakSimon Maltais
Oct 16, 2015·The Journal of Thoracic and Cardiovascular Surgery·Francis D Pagani
Nov 1, 2015·The Journal of Thoracic and Cardiovascular Surgery·Daniel J Goldstein
Dec 17, 2015·Journal of the American College of Cardiology·Nir UrielMandeep R Mehra
Sep 30, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Amelia K BoehmeNita A Limdi
Jul 17, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Gardner L YostGeetha Bhat
Jul 26, 2015·The Annals of Thoracic Surgery·Fenton H McCarthyNimesh D Desai
May 7, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Omar Wever-PinzonVeli K Topkara
May 3, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yu XiaDaniel Goldstein
Aug 6, 2015·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Tomoyuki TakuraYoshiki Sawa
Dec 5, 2014·Journal of Cardiac Surgery·Robert M AdamsonWalter P Dembitsky
Aug 19, 2015·Journal of Cardiac Surgery·Charles T KlodellWalter Dembitsky
Aug 26, 2015·Journal of Thrombosis and Haemostasis : JTH·S SusenP J Lenting
Nov 7, 2015·Current Problems in Cardiology·Navin K KapurMichael S Kiernan
May 11, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joshua Z WilleyPaolo C Colombo
Sep 14, 2015·The Journal of Thoracic and Cardiovascular Surgery·Walter F DeNinoJohn S Ikonomidis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Related Papers

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Zumrut T DemirozuO H Frazier
Journal of the American College of Cardiology
Matthew C BunteMaria M Mountis
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Raffaele CarusoOberdan Parodi
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Sangjin LeeRanjit John
© 2022 Meta ULC. All rights reserved