Interatrial Dyssynchrony May Contribute to Heart Failure Symptoms in Patients with Preserved Ejection Fraction

Echocardiography
Laura SanchisMarta Sitges

Abstract

Heart failure (HF) with preserved ejection fraction (HFPEF) is the most prevalent type of HF in nonhospitalized patients, but its pathophysiology remains poorly understood. The aim of our study was to assess the existence of interatrial dyssynchrony (IAD), a potentially treatable condition, in the development of HF symptoms. Consecutive patients with new onset of shortening of breath, referred for suspected HF, were screened. In all cases, a transthoracic echocardiography, ECG, and determination of plasma BNP level were performed at initial consultation. Patients were diagnosed according to current guidelines. Patients with HF and reduced ejection fraction were excluded. Later, the time from P-wave onset on the ECG to peak negative strain (atrial contraction) was determined using speckle tracking echocardiography; the time difference between both atria (ms) was used as an index of IAD. Sixty-six patients were included. Mean age was 74 ± 8 years (74% female, 77% hypertensive). HFPEF patients (n = 32) showed an increased IAD as compared to subjects with non-HF (n = 34; interatrial time difference 72.7 ± 27 vs. 28 ± 7 ms, P < 0.001). IAD showed a significant correlation with BNP levels, diastolic pattern, and echocardiographic par...Continue Reading

References

Oct 31, 2001·American Heart Journal·S B Goyal, D H Spodick
Feb 22, 2005·The American Journal of Cardiology·Steffen BrucksZakariya K Shihabi
Jul 12, 2005·Current Treatment Options in Cardiovascular Medicine·Shyam Bhakta, Mark E Dunlap
Aug 16, 2005·Chest·Vignendra AriyarajahDavid H Spodick
Jan 3, 2006·Heart·J E Sanderson
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Dec 23, 2006·Progress in Cardiovascular Diseases·Hidekatsu Fukuta, William C Little
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
Mar 28, 2009·Journal of the American College of Cardiology·Carolyn S P LamMargaret M Redfield
Oct 8, 2009·Circulation. Cardiovascular Imaging·Christopher P Appleton, Sándor J Kovács
Oct 8, 2009·Circulation. Cardiovascular Imaging·Mustafa KurtSherif F Nagueh
Apr 20, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Gabriele Dell'EraUNKNOWN Novara Atrial Fibrillation (NAIF) Study Group
Sep 4, 2010·Journal of the American College of Cardiology·Barry A BorlaugMargaret M Redfield
Aug 25, 2011·Circulation. Arrhythmia and Electrophysiology·Shang-Jin KimAndrew F James
Feb 1, 2012·European Journal of Heart Failure·Jean-Christophe EicherJean-Eric Wolf

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Citations

Apr 18, 2018·Circulation. Cardiovascular Imaging·Sergio Sanchez-MartinezBart H Bijnens
Oct 12, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Theodora NikolaidouAndrew L Clark
Sep 25, 2020·Current Opinion in Cardiology·Joana AdlerStephan Rosenkranz

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