Interatrial mechanical dyssynchrony worsened atrial mechanical function in sinus node disease with or without paroxysmal atrial fibrillation

Journal of Cardiovascular Electrophysiology
Mei WangHung-Fat Tse

Abstract

Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF. We performed echocardiographic examination with tissue Doppler imaging in 30 SND patients with (n = 11) or without (n = 19) paroxysmal AF who received dual-chamber pacemakers. Tissue Doppler indexes included atrial contraction velocities (Va) and timing events (Ta) were measured at midleft atrial (LA) and right atrial (RA) wall. Intraatrial synchronicity was defined by the standard deviation and maximum time delay of Ta among 6 segments of LA (septal/lateral/inferior/anterior/posterior/anterospetal). Interatrial synchronicity was defined by time delay between Ta from RA and LA free wall. There were no differences in age, P-wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with or without AF. Patients with paroxysmal AF had lower mitral inflow A velocity (70 +/- 19 vs 91 +/- 17 cm/s, P = 0.005), LA active empting fraction (24 +/- 14 vs 36 +/- 13%, P = 0.027), mean Va of LA (2.6 +/- ...Continue Reading

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Citations

Apr 26, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mei WangHung-Fat Tse
Feb 20, 2015·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Liang ZhaoXu Liu
Feb 1, 2012·European Journal of Heart Failure·Jean-Christophe EicherJean-Eric Wolf
Nov 22, 2018·Canadian Journal of Physiology and Pharmacology·Cristina LópezMónica García-Domingo
Nov 26, 2010·Current Opinion in Cardiology·Dennis H LauPrashanthan Sanders
Oct 16, 2014·Neural Regeneration Research·Hong JiangHuaying Cai
Sep 28, 2016·Journal of Cardiovascular Pharmacology·José Ángel García-PedrazaAsunción Morán
Jun 23, 2021·Herz·Wenxing Chang, Guangsen Li
Jan 1, 2011·Current Opinion in Cardiology

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