Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury

The Journal of Clinical Investigation
K J KellyJ V Bonventre

Abstract

Studies in the rat have pointed to a role for intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of acute tubular necrosis. These studies used antibodies, which may have nonspecific effects. We report that renal ICAM-1 mRNA levels and systemic levels of the cytokines IL-1 and TNF-alpha increase 1 h after ischemia/ reperfusion in the mouse. We sought direct proof for a critical role for ICAM-1 in the pathophysiology of ischemic renal failure using mutant mice genetically deficient in ICAM-1. ICAM-1 is undetectable in mutant mice in contrast with normal mice, in which ICAM-1 is prominent in the endothelium of the vasa recta. Mutant mice are protected from acute renal ischemic injury as judged by serum creatinine, renal histology, and animal survival . Renal leukocyte infiltration, quantitated morphologically and by measuring tissue myeloperoxidase, was markedly less in ICAM-1-deficient than control mice. To evaluate whether prevention of neutrophil infiltration could be responsible for the protection observed in the mutant mice, we treated normal mice with antineutrophil serum to reduce absolute neutrophil counts to < 100 cells/mm3. These neutrophil-depleted animals were protected against ischemic renal failure. Anti-...Continue Reading

References

Sep 1, 1992·Kidney International·S L LinasJ E Repine
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L J KornbergR L Juliano
Aug 2, 1990·Nature·T A Springer
Jul 25, 1989·Nucleic Acids Research·C M BallantyneA L Beaudet
Mar 1, 1986·Stroke; a Journal of Cerebral Circulation·J M HallenbeckT J Contreras
Jan 1, 1995·Annual Review of Physiology·D N Granger, R J Korthuis
Jun 6, 1995·Biochemical and Biophysical Research Communications·H RabbG Ramirez
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·K J KellyJ V Bonventre
Jul 1, 1994·The Journal of Experimental Medicine·H XuJ C Gutierrez-Ramos
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SlighA L Beaudet
May 1, 1993·Kidney International·J V Bonventre

❮ Previous
Next ❯

Citations

Oct 16, 2002·Journal of Biomedical Materials Research·Liping TangStephen E Welty
Jun 30, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hye Ryoun JangHamid Rabb
Oct 19, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fernando N FacioEmmanuel A Burdmann
Oct 29, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Christopher Y LuJohn R Hartono
Nov 19, 2003·Life Sciences·Yeong-Hau H LienArnold L Silva
Dec 2, 2000·The American Journal of Medicine·K A Nath, S M Norby
Sep 20, 2002·The Annals of Thoracic Surgery·Jeffrey M PearlJodie Y Duffy
Nov 15, 2002·Transplantation Proceedings·C Q FeitozaA Pacheco-Silva
Oct 8, 2003·Transplantation Proceedings·B D Kahan
Jul 1, 1997·Immunology Today·J C Gutierrez-Ramos, H Bluethmann
Nov 30, 2000·Anesthesiology Clinics of North America·M Hladunewich, M H Rosenthal
Jul 31, 2001·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Y Horie, H Ishii
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Christopher G. Kevil
Oct 23, 1997·Current Opinion in Cell Biology·C G Gahmberg
Jun 24, 1999·Cytokine & Growth Factor Reviews·A Meager
May 7, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A BörjessonR Andersson
Dec 22, 1999·Clinical and Experimental Immunology·F BendjelloulH Tlaskalová-Hogenová
Feb 28, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Connie L DavisAlan H Wilkinson
Nov 25, 2003·Seminars in Nephrology·Pothana Saikumar, Manjeri A Venkatachalam
May 30, 1996·The New England Journal of Medicine·R ThadhaniJ V Bonventre
Jun 21, 2002·Surgery·Hidehisa KitadaMasao Tanaka
Jun 23, 2010·The Journal of Experimental Medicine·Yoshinori YamanishiToshio Kitamura
Jul 23, 2009·Antioxidants & Redox Signaling·Betty S van der VeenPeter Heeringa
Dec 15, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Xueguang ZhangZhong Yin
Oct 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miranda Bartels-StringerCornelis Kramers
Jul 28, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nisar A KhanRon W F de Bruin
Apr 7, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John KanellisDavid J Nikolic-Paterson
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K J Kelly, Jesus H Dominguez
Aug 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Myung-Gyu KimHyoung-Kyu Kim
May 11, 2002·Critical Care Medicine·Bruce A MolitorisTimothy A Sutton
Jun 9, 1998·Current Opinion in Nephrology and Hypertension·W Lieberthal
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·D A Hamerski, S A Santoro
Aug 5, 2000·Current Opinion in Nephrology and Hypertension·A M Sheridan, J V Bonventre
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Joseph V Bonventre
Jul 10, 2002·Current Opinion in Nephrology and Hypertension·Mariusz L KielarChristopher Y Lu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.