PMID: 8599446Oct 1, 1995Paper

Intercellular adhesion molecule 1 (ICAM-1) and bcl-2 are differentially expressed in early evolving malignant melanoma

The American Journal of Dermatopathology
K A Collins, W L White

Abstract

The expression of intercellular adhesion molecule 1 (ICAM-1), a molecule pivotal in many inflammatory and immune paracrine interactions, has been highly correlated with malignant melanoma (MM) progression. Because numerous parallels exist between tissues of neural crest origin and the immune system in the regulation of postmitotic cell survival, ICAM-1 expression was studied in MM and compared with that of B-cell lymphoma/leukemia 2 protein (bcl-2 oncoprotein), an important regulator in prolonging lymphoid cell survival by blocking programmed cell death. Frozen sections from 33 cases were studied by immunoperoxidase techniques: 14 primary MM (five in situ), nine metastatic MM (one epidermotropic), four melanocytic nevi, and six normal skin controls. The percentages of the cells that stained and their intensities (0-4+) were graded. Both ICAM-1 (90%, 3-4+) and bcl-2 (95%, 2-4+) were strongly expressed in all nine metastases, including the epidermotropic disease extension. Bcl-2 strongly decorated the tumor cells in all 14 cases of primary MM (80%, 2-4+); in the five in situ MM, bcl-2 stained the atypical melanocytes at the dermal-epidermal junction (DEJ) and throughout the epidermis (75%, 1-2+). In contrast, ICAM-1 was negative ...Continue Reading

Citations

Oct 2, 2001·Pharmacology & Therapeutics·M LeszczynieckaP B Fisher
Mar 27, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liqing ZhuangPeter Hersey
May 29, 2004·The American Journal of Dermatopathology·Anneli R BowenDouglas Grossman
Jun 24, 2008·World Journal of Surgical Oncology·Marília B Espíndola, Oly C Corleta
Jul 27, 2004·American Journal of Clinical Pathology·Pamela M Guerriere-KovachMark R Wick
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·A PorgadorJ L Strominger
Jan 22, 2003·The Journal of Investigative Dermatology·Anneli R BowenDouglas Grossman
Dec 14, 1999·The Journal of Investigative Dermatology·D GrossmanD C Altieri
Apr 21, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·M LomutoA Giuliani
Mar 20, 2001·Melanoma Research·J A ShannonG J Mann
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·D Mehregan, D Mehregan

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