PMID: 8974619Oct 1, 1995Paper

Intercellular adhesion molecule-1 (ICAM-1) upregulation in human brain tumors as an expression of increased blood-brain barrier permeability

Brain Pathology
A S LossinskyH M Wiśniewski

Abstract

The distribution of intercellular adhesion molecule (ICAM-1) binding sites was studied in the microvasculature of several types of human brain tumor biopsies (angioma, glioblastoma multiforme and meningioma). Immunoelectron microscopy was performed with the application of immuno-HRP or -gold probes using a pre-embedding technique. Ultrastructural analysis demonstrated a pronounced ICAM-1 upregulation on the luminal EC and/or perivascular surfaces. Reaction product for ICAM-1 was observed associated with some but not all blood vessels of the tumors examined. The strongest reaction product was noted associated with the angioma cases with lesser expression observed on the glioblastoma multiforme and meningioma cases. The reaction product using immuno-HRP probe was observed most pronounced on the luminal endothelial cell surface and also within vesiculo-tubular structures. Concentrated immunosignals with gold label were often expressed on EC microvilli. These data suggest that several types of brain tumors are actively involved in the process of upregulating ICAM-1, presumably for tumor cell adhesion and trafficking, the process of angiogenesis or both. We suggest that the ICAM-1-positive vesiculo-tubular structures reflect special...Continue Reading

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Citations

Aug 8, 2008·Expert Reviews in Molecular Medicine·Joshua C AndersonCandece L Gladson
Mar 18, 1999·Pathology Oncology Research : POR·M GrafH F Otto
Nov 7, 2002·In Vitro Cellular & Developmental Biology. Animal·Ronald E UngerC James Kirkpatrick
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May 19, 2006·FEMS Immunology and Medical Microbiology·Abdul MatinNaveed Ahmed Khan
Jan 11, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Olfa MasmoudiMarie-Christine Tonon
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Jul 10, 2020·Neuro-oncology Advances·Casmir TurnquistCurtis C Harris
Nov 21, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Hui LiuWei Lu

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