PMID: 9542581May 23, 1998Paper

Intercellular adhesion molecule-1 (ICAM-1) expression in the liver of patients with extrahepatic cholestasis

Acta histochemica
M V Gulubova

Abstract

ICAM-1 mediates the recruitment of neutrophils through the endothelium to the site of inflammation by the ICAM-1/Mac-1 and ICAM-1/LFA-1 adhesion pathways. In extrahepatic cholestasis, recruitment of neutrophils is a main feature of the inflammatory infiltrate in areas of parenchymal damage. The aim of the present study was to describe the light and electron microscopical localization of ICAM-1 expression in the liver of cholestatic patients. The peroxidase-antiperoxidase technique was used. Increased ICAM-1 expression was detected on sinusoidal endothelial and Kupffer cells. A de novo ICAM-1 expression was described on some Ito cells and the sinusoidal hepatocyte membrane in areas of parenchymal injury. In the portal areas of livers of cholestatic patients, ICAM-1 was observed on the endothelial surface of portal veins and on hepatic arteries. Occasionally, ICAM-1 was found on the surface of bile duct epithelia. It is suggested that ICAM-1 expression is up-regulated by cytokines like TNF-alpha, IL-1 and interferons released from activated Kupffer cells. The mechanisms of ICAM-1 upregulation and neutrophil recruitment in the liver during extrahepatic cholestasis are discussed.

References

Mar 1, 1992·Immunology Today·G A ZimmermanT M McIntyre
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D H AdamsJ M Neuberger
Aug 2, 1990·Nature·T A Springer
Dec 1, 1990·The Journal of Cell Biology·M S DiamondT A Springer
Jun 15, 1990·Annals of Internal Medicine·G L BirdR S Williams
Jul 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R VolpesV J Desmet
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C J McClain, D A Cohen
Sep 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R De VosV Desmet
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D H AdamsW Newman
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M MoritaT Akaike
Aug 15, 1994·International Journal of Cancer. Journal International Du Cancer·F AoudjitM Audette
May 1, 1993·Clinical and Experimental Rheumatology·A Fischer
Feb 1, 1993·Seminars in Liver Disease·M WinnockC Balabaud
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua
Jun 6, 1996·The New England Journal of Medicine·P S Frenette, D D Wagner
Sep 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases· HellerbrandR A Rippe
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M OhtsukaN Nakajima
Jun 13, 2012·Clinical Reviews in Allergy & Immunology·Kazuhito KawataChristopher L Bowlus

❮ Previous
Next ❯

Citations

Nov 7, 2006·Pediatric Surgery International·Savaş DemirbilekNilufer Ozatay
Nov 26, 2009·Toxicology and Applied Pharmacology·Katryn AllenBryan L Copple
Jun 26, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Man LiJames L Boyer
Jun 14, 2017·Molecular Aspects of Medicine·Man LiJames L Boyer
Oct 18, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jaspreet S GujralHartmut Jaeschke
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jaspreet S GujralHartmut Jaeschke
Mar 26, 2003·Cell Death and Differentiation·C WillbergP Klenerman
Feb 4, 2003·Journal of Pineal Research·Yoshiji OhtaTeruaki Kishikawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.