PMID: 8598300Mar 15, 1996Paper

Intercellular C-signaling in Myxococcus xanthus involves a branched signal transduction pathway

Genes & Development
Lotte Søgaard-AndersenD Kaiser

Abstract

C-factor, the product of the csgA gene, is a cell-surface associated short-range intercellular signaling protein in Myxococcus xanthus. C-factor is required for at least four responses during starvation-induced fruiting body morphogenesis: rippling, aggregation, sporulation, and full expression of the csgA gene, all of which fail in a csgA mutant. To analyze the C-factor signaling pathway, eight Tn5 lac insertion mutants that began but failed to complete fruiting body aggregation were characterized. Seven of the insertions identified genes whose products function in the csgA signaling pathway. The seven mutants were differentially deficient in the C-factor responses, and could be divided into two classes on the basis of those differences. On one hand, the four mutants in class I were deficient in rippling and aggregation, but sporulated and produced C-factor at wild-type levels. The Tn5 lac insertions in the class I mutants mapped to the frz locus, which encodes a signal transduction system that controls the frequency of single cell reversals. On the other hand, mutants carrying any of the three closely linked class II Tn5 lac insertions had deficiencies in all four C-factor responses. Because the sporulation defect in the clas...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D Kaiser
Sep 1, 1992·Trends in Genetics : TIG·L Avery, S Wasserman
Mar 1, 1992·Genes & Development·S LiL J Shimkets
Dec 1, 1990·Microbiological Reviews·L J Shimkets
Mar 1, 1991·Journal of Bacteriology·H W ChenL J Shimkets
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S K Kim, D Kaiser
Sep 1, 1990·Journal of Bacteriology·L J Shimkets, H Rafiee
Jan 1, 1990·Journal of Bacteriology·T J Hagen, L J Shimkets
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W R McCleary, D R Zusman
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J McBrideD R Zusman
Jun 1, 1989·Journal of Bacteriology·H G Rhie, L J Shimkets
Nov 1, 1989·Journal of Bacteriology·R A Weinberg, D R Zusman
Jan 1, 1988·Molecular & General Genetics : MGG·L J Shimkets, S J Asher
Jan 1, 1985·Molecular & General Genetics : MGG·B D Blackhart, D R Zusman
Sep 1, 1986·Developmental Biology·L KroosD Kaiser
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B D Blackhart, D R Zusman
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L Kroos, D Kaiser
Jan 1, 1983·Molecular & General Genetics : MGG·L Avery, D Kaiser
Jul 1, 1982·Journal of Bacteriology·J M Kuner, D Kaiser
Oct 1, 1982·Journal of Bacteriology·L J Shimkets, D Kaiser
Oct 1, 1982·Journal of Bacteriology·L J Shimkets, D Kaiser
Feb 1, 1995·Molecular Microbiology·K Kashefi, P L Hartzell
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·Q HeL J Shimkets
Sep 1, 1994·Microbiological Reviews·J D Gross
Dec 1, 1994·Genes & Development·B Sager, D Kaiser
Jul 1, 1994·Trends in Genetics : TIG·A Martinez Arias
Jan 6, 1994·Nature·E SiegfriedN Perrimon
Aug 1, 1993·Molecular Microbiology·W ShiD R Zusman
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·B Sager, D Kaiser

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Citations

Jun 23, 2006·Applied Microbiology and Biotechnology·Toshiyuki Ueki, Sumiko Inouye
Apr 2, 2005·Current Opinion in Microbiology·Dale Kaiser, Rosa Yu
Nov 11, 2003·Journal of Microbiological Methods·Lars Jelsbak, Lotte Søgaard-Andersen
Oct 13, 2001·Trends in Microbiology·P J Bonner, L J Shimkets
Jun 26, 2003·Trends in Microbiology·Judith P Armitage
Dec 21, 2000·Current Opinion in Microbiology·L Jelsbak, L Søgaard-Andersen
Mar 26, 2004·Nature Reviews. Microbiology·Dale Kaiser
Jun 3, 2006·Journal of Bacteriology·Martin OvergaardLotte Søgaard-Andersen
Nov 13, 2007·Journal of Bacteriology·Xingqi ShiLotte Søgaard-Andersen
Dec 26, 2006·Journal of Bacteriology·Thomas M A Gronewold, Dale Kaiser
Nov 26, 2002·Journal of Bacteriology·Takayuki HoriuchiTeruya Komano
Jan 25, 2002·Journal of Bacteriology·Thomas M A Gronewold, Dale Kaiser
Sep 2, 2003·Journal of Bacteriology·Anders A Rasmussen, Lotte Søgaard-Andersen
Feb 6, 2004·Journal of Bacteriology·Dale Kaiser, Roy Welch
Feb 18, 2006·Journal of Bacteriology·Michelle E DiodatiAnthony G Garza
Jan 19, 1999·Annual Review of Microbiology·J A Shapiro
Jul 11, 2006·Annual Review of Microbiology·Dale Kaiser
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·M Fontes, D Kaiser
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·B JulienA Garza
Jan 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lars JelsbakDale Kaiser
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·R Welch, D Kaiser
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Poorna ViswanathanLee Kroos
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·John R Kirby, David R Zusman
Feb 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lee Kroos
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·L Jelsbak, L Søgaard-Andersen
Feb 28, 2009·Current Opinion in Microbiology·Matthew G Blango, Matthew A Mulvey
Mar 12, 2016·Science·Yi-Wei ChangGrant J Jensen
Jul 28, 2005·Molecular Microbiology·Vinh D PhamMitchell Singer
Mar 27, 2003·Molecular Microbiology·Lotte Søgaard-AndersenAnders Aa Rasmussen

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