Intercellular communication in the vascular wall: a modeling perspective.

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Sridevi NagarajaNikolaos Michael Tsoukias

Abstract

Movement of ions (Ca(2+) , K(+) , Na(+) , and Cl(-) ) and second messenger molecules like inositol 1, 4, 5-trisphosphate inside and in between different cells is the basis of many signaling mechanisms in the microcirculation. In spite of the vast experimental efforts directed toward evaluation of these fluxes, it has been a challenge to establish their roles in many essential microcirculatory phenomena. Recently, detailed theoretical models of calcium dynamics and plasma membrane electrophysiology have emerged to assist in the quantification of these intra and intercellular fluxes and enhance understanding of their physiological importance. This perspective reviews selected models relevant to estimation of such intra and intercellular ionic and second messenger fluxes and prediction of their relative significance to a variety of vascular phenomena, such as myoendothelial feedback, conducted responses, and vasomotion.

References

Jul 1, 1978·The Journal of Physiology·G D Hirst, T O Neild
May 1, 1991·The American Journal of Physiology·L K MooreJ M Burt
Oct 24, 1986·Science·V VerselisM V Bennett
Feb 1, 1970·Circulation Research·B R Duling, R M Berne
Sep 1, 1994·Biophysical Journal·G J ChristS V Ramanan
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·K A DoraB R Duling
Jan 21, 2000·Hypertension·W F Jackson
Apr 25, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P R BrinkG J Christ
Feb 17, 2001·American Journal of Physiology. Heart and Circulatory Physiology·A SchusterJ J Meister
Apr 28, 2001·Circulation Research·H PengH Nilsson
Jun 13, 2001·Journal of Theoretical Biology·D Goldman, A S Popel
Mar 14, 2002·The Journal of Membrane Biology·A Leaf, Y F Xiao
Jun 13, 2002·Clinical and Experimental Pharmacology & Physiology·Kenichi GotoMitsuo Iida
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Geoffrey G EmersonSteven S Segal
Jun 10, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Kim A DoraBrian R Duling
Jul 9, 2004·Biophysical Journal·Michèle KoenigsbergerJean-Jacques Meister
Sep 24, 2004·Physiology·Xavier F FigueroaBrian R Duling
Mar 29, 2005·Biophysical Journal·Michèle KoenigsbergerJean-Jacques Meister
Apr 5, 2005·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Steven S Segal
Jul 1, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshimichi Yamamoto, Hikaru Suzuki
Jul 7, 2005·Bulletin of Mathematical Biology·Michèle KoenigsbergerJean-Jacques Meister
Mar 25, 2006·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hiromichi TakanoChristopher J Garland
Apr 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Micaela C JantziDonald G Welsh
Nov 14, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Torben R UhrenholtSteven S Segal
Jan 16, 2007·Circulation Research·Brant E IsaksonBrian R Duling
Mar 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jens Christian Brings JacobsenNiels-Henrik Holstein-Rathlou
Apr 27, 2007·American Journal of Physiology. Cell Physiology·Haroldo S SilvaNikolaos M Tsoukias
May 22, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Xavier F FigueroaBrian R Duling
Sep 28, 2007·American Journal of Physiology. Cell Physiology·Monica M Lurtz, Charles F Louis

❮ Previous
Next ❯

Citations

Mar 27, 2013·The Journal of Physiology·Sridevi NagarajaNikolaos M Tsoukias
Mar 27, 2015·Biophysical Journal·Jaimit ParikhNikolaos M Tsoukias
May 30, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Donald G Welsh, Mark S Taylor
Jan 29, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Jaimit ParikhNikolaos M Tsoukias
May 4, 2016·Annals of Biomedical Engineering·Yanhang ZhangNatalia A Trayanova
Sep 1, 2019·Animals : an Open Access Journal From MDPI·Marcela KnoxJosé L Martínez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Adam KapelaNikolaos Michael Tsoukias
Critical Reviews in Biomedical Engineering
Adam KapelaNikolaos Michael Tsoukias
American Journal of Physiology. Heart and Circulatory Physiology
Adam KapelaNikolaos Michael Tsoukias
Pflügers Archiv : European journal of physiology
Cor De Wit, Tudor M Griffith
© 2022 Meta ULC. All rights reserved