Intercellular communication via connexin43 gap junctions is required for ovarian folliculogenesis in the mouse

Developmental Biology
C L AckertG M Kidder

Abstract

The ovarian follicle in mammals is a functional syncytium, with the oocyte being coupled with the surrounding cumulus granulosa cells, and the cumulus cells being coupled with each other and with the mural granulosa cells, via gap junctions. The gap junctions coupling granulosa cells in mature follicles contain several different connexins (gap junction channel proteins), including connexins 32, 43, and 45. Connexin43 immunoreactivity can be detected from the onset of folliculogenesis just after birth and persists through ovulation. In order to assess the importance of connexin43 gap junctions for postnatal folliculogenesis, we grafted ovaries from late gestation mouse fetuses or newborn pups lacking connexin43 (Gja1(-)/Gja1(-)) into the kidney capsules of adult females and allowed them to develop for up to 3 weeks (this was necessitated by the neonatal lethality caused by the mutation). By the end of the graft period, tertiary (antral) follicles had developed in grafted normal (wild-type or heterozygote) ovaries. Most follicles in Gja1(-)/Gja1(-) ovaries, however, failed to become multilaminar, with the severity of the effect depending on strain background. Dye transfer experiments indicated that intercellular coupling between ...Continue Reading

References

Apr 1, 1990·Molecular Reproduction and Development·B A Mattson, D F Albertini
Nov 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J J Eppig
Jan 30, 1987·Science·P M Wassarman
Mar 1, 1986·The Anatomical Record·P A Mitchell, R C Burghardt
Mar 24, 1995·Science·A G ReaumeJ Rossant
Jun 1, 1994·Molecular Reproduction and Development·S Coskun, Y C Lin
Sep 1, 1993·Molecular Reproduction and Development·G ValdimarssonG M Kidder
May 15, 1996·European Journal of Biochemistry·R BruzzoneD L Paul
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·E NellesK Willecke
Sep 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R BruzzoneD A Goodenough
Feb 6, 1997·Nature·A M SimonD L Paul
Mar 1, 1997·Molecular Reproduction and Development·A G ByskovX Guoliang
Jun 1, 1996·Molecular Reproduction and Development·J J EppigK Wigglesworth
Sep 30, 1998·The European Journal of Neuroscience·D F CondorelliF Cicirata
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·A DierichP Sassone-Corsi
Dec 29, 1998·Cell·R DerynckX H Feng
Apr 1, 1999·Annual Review of Physiology·T W White, D L Paul
Apr 20, 1999·Biology of Reproduction·S C JunejaG M Kidder
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·D S HeJ M Burt
Jun 24, 1999·Molecular Endocrinology·J A ElvinM M Matzuk
Jun 26, 1999·Circulation Research·S AlcoléaD B Gros
Apr 18, 2000·Mutation Research·V Krutovskikh, H Yamasaki
Feb 28, 2001·Reproduction : the Official Journal of the Society for the Study of Fertility·C S WrightK Hardy

❮ Previous
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Citations

Oct 26, 2005·The Journal of Membrane Biology·A NgezahayoH-A Kolb
Feb 5, 2003·Biology of the Cell·Véronique Serre-BeinierPaolo Meda
Jun 24, 2003·Animal Reproduction Science·Trudee Fair
Apr 12, 2002·Trends in Endocrinology and Metabolism : TEM·Olga Epifano, Jurrien Dean
Aug 7, 2002·Trends in Endocrinology and Metabolism : TEM·Irit Granot, Nava Dekel
Aug 2, 2005·Seminars in Reproductive Medicine·Michelle Jamnongjit, Stephen R Hammes
Nov 25, 2003·Tissue Engineering·Stephanie A PangasTeresa K Woodruff
Nov 9, 2010·Stem Cells and Development·Paul W DyceJulang Li
Jul 30, 2004·Molecular Biology of the Cell·Karen MaassKlaus Willecke
Jun 4, 2002·Human Reproduction·David LevranAriel Weissman
Sep 25, 2009·Endocrine Reviews·Mark A EdsonMartin M Matzuk
Mar 5, 2009·Disease Models & Mechanisms·Dan TongGerald M Kidder
Feb 14, 2006·The Journal of Reproduction and Development·Keiichiro YogoTatsuo Takeya
Jan 15, 2011·Journal of Human Reproductive Sciences·Zhi Qin ChenHans Ingolf Nielsen
Jul 31, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Wei ShenHongkui Deng
Aug 22, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Sarah E HarrisHelen M Picton
Jul 10, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·George B JohnDiego H Castrillon
Jul 17, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Srinivas V SeekalluNorman C Rawlings
Apr 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Vicki PlaksNava Dekel
Apr 4, 2014·Stem Cells and Development·Paul W DyceGerald M Kidder
Jan 16, 2007·Canadian Journal of Physiology and Pharmacology·Ewa BorowczykAnna T Grazul-Bilska
Jun 18, 2010·Canadian Journal of Physiology and Pharmacology·Gerald M Kidder, Barbara C Vanderhyden
Mar 6, 2013·Canadian Journal of Physiology and Pharmacology·Dan LiGerald M Kidder
Apr 15, 2006·Cell Communication & Adhesion·Alexander M SimonCharity L Jackson
Dec 15, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Praveen GuruvaiahManjula Bhanoori
Oct 23, 2010·Theriogenology·E J C VerbraakC Zijlstra
Mar 5, 2016·Seminars in Cell & Developmental Biology·Dale W Laird, Christian C Naus
Oct 9, 2009·Trends in Endocrinology and Metabolism : TEM·Scott H Purcell, Kelle H Moley
Nov 11, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Zhen TengHua Zhang
Dec 29, 2007·Molecular and Cellular Endocrinology·Eran GershonNava Dekel

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