Interchangeability of 2 diphtheria-tetanus-acellular pertussis vaccines in infancy

Pediatrics
D P GreenbergBarbara J Howe

Abstract

Currently, 4 diphtheria-tetanus-acellular pertussis (DTaP) vaccines are licensed for pediatric use in the United States, and 2 are commercially available. Although a single manufacturer's DTaP vaccine should be used for all 3 doses of the primary immunization series, some circumstances result in infants receiving DTaP vaccines from more than 1 manufacturer. The purpose of this study was to evaluate the safety and immunogenicity of a mixed sequence of 2 different DTaP vaccines. In this multicenter, observer-blinded, controlled study, 449 infants were randomized into 1 of 3 groups (1:1:1 ratio) to receive Tripedia at 2, 4, and 6 months of age (control group); Tripedia at 2 and 4 months of age and Infanrix at 6 months of age; or Tripedia at 2 months and Infanrix at 4 and 6 months of age. Other vaccines were administered concurrently as separate injections according to the recommended childhood immunization schedule. Safety was monitored closely, and standard enzyme immunoassays were used to measure antibody concentrations to each antigen of the DTaP vaccines. The rates of injection-site and systemic adverse events were similar in each study group, and there were no clinically significant differences among groups after any dose. In...Continue Reading

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May 23, 2003·Current Infectious Disease Reports·Flor M. Munoz, Wendy A. Keitel
Aug 7, 2003·Expert Review of Vaccines·Sylvia H Yeh
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Mar 14, 2014·Paediatrics and International Child Health·Huseyin Anil KorkmazBelgin Unal

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