DOI: 0803.0964Mar 6, 2008Paper

Interchromatidal central ridge and transversal symmetry in early metaphasic human chromosome one

ArXiv
Orlando Argüello-Miranda, Giovanni Sáenz-Arce

Abstract

The topographic structure of Giemsa banded (G-banded) early metaphase human chromosomes adsorbed on glass was analyzed by atomic force microscope using amplitude modulation mode [AM-AFM]. Longitudinal height measurements for early metaphasic human chromosomes showed a central ridge that was further characterized by transversal height measurements. The heterochromatic regions displayed a high level of transversal symmetry, while the euchromatic ones presented several peaks across the transversal height measurements. We suggest that this central ridge and symmetry patterns point out a transitional arrangement of the early metaphase chromosome and support evidence for interchromatidal interactions prior to disjunction.

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