Intercycle delays during chemotherapy of non-small cell lung cancer in a health care resource-constrained setting and their effect on overall survival

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Navneet SinghSurinder K Jindal

Abstract

A prospective study was conducted at the lung cancer clinic of a tertiary care institute to assess the incidence of and reasons for intercycle delays (ICD) during chemotherapy of patients with non-small cell lung cancer (NSCLC). The effect of ICD on overall survival was also assessed. Data were collected for all newly diagnosed NSCLC patients who were initiated on and completed chemotherapy during a 12-month period. Differences between patients who experienced ICD (ICD+ group) versus those who did not (ICD- group) were analyzed. Survival probabilities and median survivals were calculated by Kaplan-Meier method, and group differences were analyzed using the log-rank test. Of the 118 chemonaive NSCLC patients who received chemotherapy, 100 received > or =2 cycles and were included in data analysis. A total of 441 cycles were administered with ICD amounting to 683 days being noted during 84 (19.1%) cycles in 57 patients. The most common reasons for ICD were nonavailability of blood tests reports (25.5%), severe anemia (20.2%), and hospital holidays on scheduled days of chemotherapy (9.6%). ICD+ and ICD- groups did not differ with respect to age, gender, smoking status, histology, stage of disease, baseline performance status, chem...Continue Reading

References

Oct 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·H Bozcuk, C Martin
Oct 21, 2005·Chest·Eija-Riitta SalomaaKari Liippo

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Citations

Nov 8, 2014·Lung India : Official Organ of Indian Chest Society·Navneet Singh, Digambar Behera
Sep 9, 2016·South Asian Journal of Cancer·Vanita NoronhaKumar Prabhash
Dec 20, 2012·Expert Review of Anticancer Therapy·Navneet SinghDigambar Behera
Oct 14, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M N YoganandaNavneet Singh
Nov 15, 2018·World Journal of Clinical Oncology·Kuruswamy Thurai PrasadNavneet Singh

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