Interdependence of ion transport and the action of quabain in heart muscle

British Journal of Pharmacology
M BentfeldD Proppe

Abstract

1 The influence of ouabain (0.4 muM) on contractile force and cellular Na and K concentrations was investigated in isolated left atria of the guinea-pig at rest and at different beat frequencies. Simultaneously the binding of ouabain to the tissue was determined.2 Strict dependence of rates of onset of positive iontropic action and of binding of ouabain on beat frequency are limited to conditions where no alterations of cellular Na and K concentrations occur. A correlation was observed between sodium flux per unit time and the development of positive inotropism and binding to the receptors of ouabain.3 Ouabain exerts its positive inotropic effect without affecting the intracellular Na and K concentrations in spite of the fact that under these conditions even the majority of binding sites, i.e. Na-K-adenosine triphosphatases (Na-K-ATPases), are occupied by the drug. The positive inotropic effect may be explained by a ouabain-induced conformational alteration of the Na-K-ATPase which leads to structural alterations of the plasmalemma connected with an increased availability of coupling calcium.4 Increasing the frequency of stimulation over a critical value, which appears to be determined by an overloading of the Na pump, induces ...Continue Reading

References

Jan 1, 1977·Clinical and Experimental Pharmacology & Physiology·H Lüllmann, T Peters
Oct 1, 1975·The Journal of Physiology·E Erdmann, W Hasse
Aug 19, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·H LüllmannT Rüther
Nov 1, 1972·British Journal of Pharmacology·T Godfraind, M Lesne
Jan 1, 1972·The American Journal of Cardiology·R N DeutscherR H Godlman
Jan 1, 1971·Circulation Research·J Koch-Weser
Mar 1, 1968·British Journal of Pharmacology and Chemotherapy·K KuschinskyP A van Zwieten
Jun 1, 1967·British Journal of Pharmacology and Chemotherapy·K KuschinskyP A van Zwieten
Jan 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·S GARB, M PENNA
Oct 1, 1963·The American Journal of Physiology·E F GERSMEYER, W C HOLLAND
Feb 15, 1964·Klinische Wochenschrift·K REPKE
Jul 1, 1969·The Journal of General Physiology·R L PostA K Sen

❮ Previous
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Citations

Nov 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·K TakedaI S Shieh
Dec 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·F Ebner, H Siegl
May 15, 1978·European Journal of Pharmacology·S YamamotoT M Brody
Dec 20, 1979·European Journal of Pharmacology·T Godfraind, J Ghysel-Burton
Mar 7, 1980·European Journal of Pharmacology·C I Lin, M Vassalle
May 6, 1983·European Journal of Pharmacology·R H KennedyT M Brody
Nov 19, 1986·European Journal of Pharmacology·M Borchard, U Ravens
Sep 2, 1987·European Journal of Pharmacology·P Abete, M Vassalle
Jan 17, 1991·European Journal of Pharmacology·D WermelskirchenB Wilffert
Feb 13, 1999·European Journal of Pharmacology·H R LuF De Clerck
Sep 7, 1978·The New England Journal of Medicine·T W Smith
Feb 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·E Wettwer, U Ravens
Apr 24, 2007·Basic & Clinical Pharmacology & Toxicology·Guadalupe BravoFengyang Huang
Jul 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
May 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Mar 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
May 1, 1981·Clinical and Experimental Pharmacology & Physiology·A J MarshR R Taylor
Mar 1, 1985·British Journal of Pharmacology·S Herzig, K Mohr
May 1, 1984·British Journal of Pharmacology·S Herzig, K Mohr
Dec 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N AskenasyG Navon
Oct 25, 1986·British Medical Journal·R Tritapepe, C di Padova
Jan 1, 1981·Acta Medica Scandinavica. Supplementum·W G Nayler
Mar 1, 1983·Drug Intelligence & Clinical Pharmacy·A A Nanji
Oct 15, 1979·Biochemical Pharmacology·A De Pover, T Godfraind
Aug 7, 1979·Biochimica Et Biophysica Acta·S YamamotoT M Brody

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