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Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding

Molecular Biology and Evolution

Oct 28, 2017

Charles W Carter, Peter R Wills

Abstract

Genetic coding is generally thought to have required ribozymes whose functions were taken over by polypeptide aminoacyl-tRNA synthetases (aaRS). Two discoveries about aaRS and their interactions with tRNA substrates now furnish a unifying rationale for the opposite conclusion: that the ...read more

Mentioned in this Paper

Central
Electric Impedance
Exons
Genes
Enzymes, antithrombotic
Inversion Mutation Abnormality
MT-TA gene
Catalytic RNA
Virus Replication
Triplet Codon-amino Acid Adaptor Activity
16
4
3
56
Paper Details
References
  • References125
  • Citations9
12345...

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Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding

Molecular Biology and Evolution

Oct 28, 2017

Charles W Carter, Peter R Wills

PMID: 29077934

DOI: 10.1093/molbev/msx265

Abstract

Genetic coding is generally thought to have required ribozymes whose functions were taken over by polypeptide aminoacyl-tRNA synthetases (aaRS). Two discoveries about aaRS and their interactions with tRNA substrates now furnish a unifying rationale for the opposite conclusion: that the ...read more

Mentioned in this Paper

Central
Electric Impedance
Exons
Genes
Enzymes, antithrombotic
Inversion Mutation Abnormality
MT-TA gene
Catalytic RNA
Virus Replication
Triplet Codon-amino Acid Adaptor Activity
16
4
3
56

Similar Papers Found In These Feeds

Riboswitches and Ribozymes

Ribozymes are catalytic RNAs that interact with a variety of small molecule substrates and cofactors, the intracellular abundance of which are sensed by riboswitches that modulate transcription, RNA stability, or translation. Here is the latest research.

tRNA synthetases

Aminoacyl-tRNA synthetases, also known as tRNA-ligases, are enzymes that attaches the appropriate amino acid onto its transfer RNA. Mutations in these enzymes have been linked to several diseases including Charcot-Marie-Tooth and cancer. Here is the latest research.

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Paper Details
References
  • References125
  • Citations9
12345...
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